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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	mianserin
Molecular formula	C18H20N2
IUPAC name	5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
Molecular weight	264.372
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.4
Synonyms	DB06148 EINECS 246-088-6 KBio2_002301 Lopac0_000744 Mianserina [INN-Spanish] (+-)-Athymil NCGC00015656-05 24219-97-4 NINDS_000844 AM20041174 Prestwick2_000099 BRD-A19661776-001-01-5 Spectrum4_001260 CCG-204829 UEQUQVLFIPOEMF-UHFFFAOYSA-N DivK1c_000844 HMS2089A04 KBio3_003016 Mianserin (INN) Mianserinum 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-09 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene Oprea1_703627 BDBM50222218 SCHEMBL18020 BRN 0755346 Tolvan CHEMBL6437 DSSTox_RID_76974 IDI1_000844 L000736 Mianserin [INN:BAN] Mianseryna [Polish] 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine # NCGC00024926-03 AC1L1HLP Prestwick0_000099 BPBio1_000064 Spectrum2_001203 C18H20N2 Tox21_110191 D0R6RO Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- FT-0697022 KBio2_004869 LS-61197 Mianserine NCGC00015656-06 5-methyl-2,5-diazatetracyclo[13.4.0.0;{2,7}.0;{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval AN-15691 Prestwick3_000099 BRD-A19661776-003-05-2 Spectrum5_001772 CHEBI:51137 X5019 DSSTox_CID_3317 HSDB 7182 KBioGR_001820 mianserin a Mianserinum [INN-Latin] NCGC00015656-10 78684-63-6 PDSP1_001532 Biomol-NT_000135 SPBio_000986 BSPBio_000058 Tolvin (TN) CS-2078 DTXSID6023317 KBio1_000844 Lerivon Mianserina NCGC00015656-04 21535-47-7 (mono-hydrochloride) NCGC00024926-04 AKOS005216268 Prestwick1_000099 BPBio1_000331 Spectrum3_001836 CAS-24219-97-4 Tox21_110191_1 Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- GTPL135 KBio2_007437 Mianserine [INN-French] 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine NCGC00015656-08 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval (TN) API0000656 SBI-0050722.P003 BRD-A19661776-003-16-9 Spectrum_001810 DSSTox_GSID_23317 HY-B0188 KBioSS_002303 Mianserin Monohydrochloride Mianseryna 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-12 AC-631 PDSP2_001516 Bolvidon (TN) SPBio_001997 BSPBio_003511 Tolvon (TN) D08216 [ Show all ]
Inchi Key	UEQUQVLFIPOEMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
PubChem CID	4184
ChEMBL	CHEMBL6437
IUPHAR	135
BindingDB	N/A
DrugBank	DB06148
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	872.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	498.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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