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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	CHEMBL1956200
Molecular formula	C12H16N2O3S
IUPAC name	2-[1-(2-methylsulfonylphenoxy)ethyl]-4,5-dihydro-1H-imidazole
Molecular weight	268.331
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.6
Synonyms	BDBM50419882
Inchi Key	BUVSDNNKXQXCRO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H16N2O3S/c1-9(12-13-7-8-14-12)17-10-5-3-4-6-11(10)18(2,15)16/h3-6,9H,7-8H2,1-2H3,(H,13,14)
PubChem CID	57400959
ChEMBL	CHEMBL1956200
IUPHAR	N/A
BindingDB	50419882
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10000.0 nM	PMID22341244	BindingDB,ChEMBL
Intrinsic activity	0.45 -	PMID22341244	ChEMBL
Ki	51286.0 nM	PMID22341244	BindingDB
Ki	51286.1 nM	PMID22341244	ChEMBL

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