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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCID 44319559
Molecular formulaC143H214N42O47S
IUPAC name(3R)-3-[[(2R)-5-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R,3S)-2-[[(2R,3S)-2-[[2-[[(2R)-5-amino-2-[[(2R)-2-[[(2R)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-4-amino-1-[[(2R,3S)-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxo-4-sulfanylbutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3305.59
Hydrogen bond acceptor53
Hydrogen bond donor52
XlogP-19.5
SynonymsN/A
Inchi KeyBUTKKOZVNAJNLB-AGEBCJOZSA-N
Inchi IDInChI=1S/C143H214N42O47S/c1-66(2)46-90(125(216)166-89(41-45-233)124(215)174-96(53-108(149)199)130(221)178-100(60-186)70(8)191)169-129(220)95(51-76-57-157-82-23-15-14-22-80(76)82)173-123(214)88(37-40-107(148)198)167-139(230)113(68(5)6)184-134(225)94(48-73-20-12-11-13-21-73)172-131(222)97(54-110(201)202)175-122(213)87(36-39-106(147)197)161-116(207)69(7)160-119(210)84(25-18-43-155-142(150)151)162-120(211)85(26-19-44-156-143(152)153)164-137(228)103(63-189)181-133(224)99(56-112(205)206)176-126(217)91(47-67(3)4)168-127(218)92(49-74-27-31-78(194)32-28-74)170-121(212)83(24-16-17-42-144)163-136(227)102(62-188)180-128(219)93(50-75-29-33-79(195)34-30-75)171-132(223)98(55-111(203)204)177-138(229)104(64-190)182-140(231)115(72(10)193)185-141(232)114(71(9)192)183-109(200)59-158-118(209)86(35-38-105(146)196)165-135(226)101(61-187)179-117(208)81(145)52-77-58-154-65-159-77/h11-15,20-23,27-34,57-58,60,65-72,81,83-104,113-115,157,187-195,233H,16-19,24-26,35-56,59,61-64,144-145H2,1-10H3,(H2,146,196)(H2,147,197)(H2,148,198)(H2,149,199)(H,154,159)(H,158,209)(H,160,210)(H,161,207)(H,162,211)(H,163,227)(H,164,228)(H,165,226)(H,166,216)(H,167,230)(H,168,218)(H,169,220)(H,170,212)(H,171,223)(H,172,222)(H,173,214)(H,174,215)(H,175,213)(H,176,217)(H,177,229)(H,178,221)(H,179,208)(H,180,219)(H,181,224)(H,182,231)(H,183,200)(H,184,225)(H,185,232)(H,201,202)(H,203,204)(H,205,206)(H4,150,151,155)(H4,152,153,156)/t69-,70+,71+,72+,81-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100+,101-,102-,103-,104-,113-,114-,115-/m1/s1
PubChem CID44319559
ChEMBLCHEMBL409611
IUPHARN/A
BindingDB50059355
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %PMID9258362ChEMBL
Activity0.3 %PMID9258362ChEMBL
IC50500.0 nMPMID9258362BindingDB,ChEMBL
Kd562.0 nMPMID9258362BindingDB
Kd562.34 nMPMID9258362ChEMBL

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