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GPCR

Name5-hydroxytryptamine receptor 5A
SpeciesMus musculus (Mouse)
GeneHtr5a
SynonymMR22
Htr5
5HT5-
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
5-HT5alpha
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProtP30966
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3597
IUPHAR10
DrugBankN/A

Ligand

NameCHEMBL446356
Molecular formulaC23H26N2
IUPAC name5-methyl-2-[(E)-5-phenylpent-2-enyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
Molecular weight330.475
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP4.6
SynonymsBDBM50132089
5-Methyl-2-(5-phenyl-pent-2-enyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Inchi KeyTZMGYAZWNMOAIK-YCRREMRBSA-N
Inchi IDInChI=1S/C23H26N2/c1-24-22-14-8-7-13-20(22)21-18-25(17-15-23(21)24)16-9-3-6-12-19-10-4-2-5-11-19/h2-5,7-11,13-14H,6,12,15-18H2,1H3/b9-3+
PubChem CID44351100
ChEMBLCHEMBL446356
IUPHARN/A
BindingDB50132089
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki350.0 nMPMID12930153BindingDB,ChEMBL

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