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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL416980
Molecular formula	C16H24ClN3O4
IUPAC name	methyl 2-[5-amino-4-chloro-2-[2-(diethylamino)ethylcarbamoyl]phenoxy]acetate
Molecular weight	357.835
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.5
Synonyms	TYZOHBMALJGRIB-UHFFFAOYSA-N [5-Amino-4-chloro-2-(2-diethylamino-ethylcarbamoyl)-phenoxy]-acetic acid methyl ester BDBM50023862 SCHEMBL9777161 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(2-methoxy-2-oxoethoxy)benzamide
Inchi Key	TYZOHBMALJGRIB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24ClN3O4/c1-4-20(5-2)7-6-19-16(22)11-8-12(17)13(18)9-14(11)24-10-15(21)23-3/h8-9H,4-7,10,18H2,1-3H3,(H,19,22)
PubChem CID	14116888
ChEMBL	CHEMBL416980
IUPHAR	N/A
BindingDB	50023862
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<40.0 mg.kg-1	PMID3397992	ChEMBL
IC50	<1000.0 nM	PMID3397992	BindingDB,ChEMBL

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