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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(3) dopamine receptor
Species	Chlorocebus aethiops (Green monkey)
Gene	DRD3
Synonym	Dopamine D3 receptor
Disease	N/A for non-human GPCRs
Length	400
Amino acid sequence	MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDRAHLELKRYYSICQDTALGGPGFQERGGELKREERTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P52703
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2304406
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL446892
Molecular formula	C23H23F3N2O
IUPAC name	1-[(1-phenylpyrrol-3-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperidin-4-ol
Molecular weight	400.445
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.2
Synonyms	1-(1-Phenyl-1H-pyrrol-3-ylmethyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol BDBM50048232 4-[3-(Trifluoromethyl)phenyl]-1-[(1-phenyl-1H-pyrrol-3-yl)methyl]piperidin-4-ol
Inchi Key	TVQJPTVBALUGFW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23F3N2O/c24-23(25,26)20-6-4-5-19(15-20)22(29)10-13-27(14-11-22)16-18-9-12-28(17-18)21-7-2-1-3-8-21/h1-9,12,15,17,29H,10-11,13-14,16H2
PubChem CID	10597114
ChEMBL	CHEMBL446892
IUPHAR	N/A
BindingDB	50048232
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	420.0 nM	PMID8523409	BindingDB,ChEMBL

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