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GLASS

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GPCR

Name	D(2) dopamine receptor
Species	Canis lupus familiaris (Dog)
Gene	DRD2
Synonym	Dopamine D2 receptor
Disease	N/A for non-human GPCRs
Length	443
Amino acid sequence	MDPLNLSWYDDDLESQNWSRPFNGSEGKPGKPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTERSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTADSPAKPEKNGHAKDHPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCECNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	Q9GJU1
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2703
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	metoclopramide
Molecular formula	C14H22ClN3O2
IUPAC name	4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Molecular weight	299.799
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.6
Synonyms	4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide Z2196779550 Gastrosil Moriperan IDI1_000069 NCGC00015643-04 AC1L1HKD KBio3_001527 NCGC00024440-03 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- L4YEB44I46 O-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-(8CI) BPBio1_001100 Maxolon (TN) Plasil (pharmaceutical) C14H22ClN3O2 Methochlopramide Prestwick3_000209 cid_23659 Reglan (Salt/Mix) D08VYV 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide SPBio_002118 DSSTox_RID_80719 Metoclol 4-Amino-5-chloro-2-methoxy-N-(.beta.-diethylaminoethyl)benzamide STL257058 Emperal Metoclopramide [INN:BAN:JAN] Metoclopramidum 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride Gimoli N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide 7232-21-5 (mono-hydrochloride) KB-189202 NCGC00015643-07 AKOS000280832 KM1470 Neu-Sensamide Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- LS-20038 Parmid BRD-K75641298-003-16-9 Megaldrate Pramiel CCG-204847 Metochlopramide Primperan (TN) Clopra-Yellow (metaclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide SBB037841 Degan (TN) Spectrum4_000964 EINECS 206-662-9 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide Tox21_110188 Gastrese Gastromax Metramid 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride HSDB 7841 NCGC00015643-02 AB00053498_14 KBio2_004686 NCGC00015643-11 ARONIS24307 KS-5055 o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- bmse000779 Maxolon Peraprin BSPBio_002027 Metadrate Prestwick1_000209 Regla CTK8G1095 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide SCHEMBL18629 DSSTox_CID_25169 364M625 ST024773 Emetid Metoclopramide Monohydrochloride, Monohydrate 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (metoclopramide) UNII-L4YEB44I46 4-amino-5-chloro-N-[2-(diethylamino)-ethyl]-2-methoxybenzamide ZINC1530716 Gastrotablinen Mygdalon 5-Chloro-2-methoxyprocainamide Imperan NCGC00015643-05 AJ-26684 KBioGR_001307 NCGC00024440-04 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- (9CI) Lopac-M-0763 o-Anisamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]- BRD-K75641298-001-01-5 MCULE-8566255889 Pms-Metoclopramide CAS-364-62-5 Methoclopramide Primperan Clopra Reglan (TN) 2-Methoxy-5-chloroprocainamide Spectrum2_001720 DTXSID6045169 Metoclopramida 4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide Terperan Eucil Metoclopramide, European Pharmacopoeia (EP) Reference Standard Gastro-Timelets Metoclopramidum [INN-Latin] 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide GTPL241 n-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- AB00053498 KBio1_000069 NCGC00015643-08 AN-44542 KS-00000GNS NINDS_000069 Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- Maxeran Paspertin BRN 1884366 Metaclopramide Pramin Cerucal Metochloropramide Pylomid (TN) Clopromate (metoclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide SBI-0050740.P004 DEL 1267 2576-84-3 (di-hydrochloride) Spectrum5_001449 Elieten Metoclopramide (JP15/INN) 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide Tox21_110188_1 US9132134, Metoclopramide Gastronerton MolPort-000-883-854 4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride HY-17382 NCGC00015643-03 AB1009457 KBio2_007254 NCGC00015643-13 BDBM48320 L001078 o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- (8CI) BPBio1_000217 Maxolon (Salt/Mix) Plasil C07868 Metamide Prestwick2_000209 CHEMBL86 Reglan D00726 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide SPBio_001740 DSSTox_GSID_45169 4 Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide ST077151 Emitasol Metoclopramide Omega 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide(Metoclopramide) 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide Gastrotem N-(2-diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide 54143-57-6 (mono-hydrochloride, mono-hydrate) J90028 NCGC00015643-06 AK468880 KBioSS_002118 NCI60_003185 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-(9CI) Lopac0_000762 Octamide BRD-K75641298-003-05-2 Meclopran Pramidin CAS-7232-21-5 Methoxychlorprocainamide Primperan (tablet) (Salt/Mix) CLOPRA-"YELLOW" (4-amino-5-chloro-2-methoxyphenyl)-N-[2-(diethylamino)ethyl]carboxamide Reliveran DB01233 232M215 Spectrum3_000504 Duraclamid Metoclopramida [INN-Spanish] 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Terperan (TN) FT-0628931 Metoclopramide, VETRANAL(TM), analytical standard Gastrobid Metocobil 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; Methoxychloroprocainamide HMS2089G16 NCGC00015643-01 AB00053498-13 KBio2_002118 NCGC00015643-09 Apo-Metoclop KS-000048I1 Nu-Metoclopramide Biomol-NT_000082 Maxeran (TN) Paspertin (Salt/Mix) BSPBio_000197 Metaclopromide Prestwick0_000209 CHEBI:107736 Reclomide CS-1064 SC-81367 DivK1c_000069 364-62-5 Spectrum_001638 Elieten (TN) Metoclopramide (JP17/INN) 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (Mcp) TTWJBBZEZQICBI-UHFFFAOYSA-N [ Show all ]
Inchi Key	TTWJBBZEZQICBI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
PubChem CID	4168
ChEMBL	CHEMBL86
IUPHAR	241
BindingDB	48320
DrugBank	DB01233
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	0.36 mg.kg-1	PMID3397992	ChEMBL
Inhibition	100.0 %	PMID2139471	ChEMBL

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