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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	G-protein coupled receptor 35
Species	Mus musculus (Mouse)
Gene	Gpr35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A for non-human GPCRs
Length	307
Amino acid sequence	MNSTTCNSTLTWPASVNNFFIIYSALLLVLGLLLNSVALWVFCYRMHQWTETRIYMTNLAVADLCLLCSLPFVLYSLKYSSSDTPVCQLSQGIYLANRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAAAVCVALWVIVVTSLVVRWRLGMQEGGFCFSSQTRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMVWANLAVFVICFLPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYYYMAREFQEASKPATSSNTPHKSQDSQILSLT
UniProt	Q9ES90
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2390813
IUPHAR	102
DrugBank	N/A

Ligand

Name	CHEMBL2392141
Molecular formula	C17H11FN2O3S
IUPAC name	4-[(Z)-[2-(2-fluorophenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
Molecular weight	342.344
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.7
Synonyms	494191-73-0 ZINC33932405 AKOS000612789 SR-01000311957 4-({2-[(2-fluorophenyl)azamethylene]-4-oxo-1,3-thiazolidin-5-ylidene}methyl)be nzoic acid 4-[2-(2-Fluoro-phenylimino)-4-oxo-thiazolidin-5-ylidenemethyl]-benzoic acid BDBM50436010 STL305283 MolPort-035-765-863 AKOS024458393 SR-01000311957-1 4-[(Z)-[2-(2-fluoroanilino)-4-oxo-1,3-thiazol-5-ylidene]methyl]benzoic acid 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid TC-G 1001 AC1NY5NL NCGC00387206-01 4-[(Z)-{(2Z)-2-[(2-fluorophenyl)imino]-4-oxo-1,3-thiazolidin-5-ylidene}methyl]benzoic acid BAS 02301157 ST50155062 [ Show all ]
Inchi Key	SYCKPHBALHXMIR-ZROIWOOFSA-N
Inchi ID	InChI=1S/C17H11FN2O3S/c18-12-3-1-2-4-13(12)19-17-20-15(21)14(24-17)9-10-5-7-11(8-6-10)16(22)23/h1-9H,(H,22,23)(H,19,20,21)/b14-9-
PubChem CID	135468531
ChEMBL	CHEMBL2392141
IUPHAR	N/A
BindingDB	50436010
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	17000.0 nM	PMID23713606	BindingDB,ChEMBL

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