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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	UNII-QQYOR9S587
Molecular formula	C18H29NO
IUPAC name	(1S,2R)-5-methoxy-1-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
Molecular weight	275.436
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.8
Synonyms	(1S,2R)-5-methoxy-1-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine Biomol-NT_000045 NCGC00024783-01 ((1S,2R)-5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine CHEBI:114198 SCHEMBL273985 (+)-UH-232 AKOS030530973 cis-(1s,2r)-(+)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin (5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine BPBio1_001271 NCGC00024783-02 (+)-(5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine 95999-12-5 Tocris-0775 (1S,2R)-(5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine BDBM50041961 cis-5-Methoxy-1-methyl-2-(di-n-propylamino)tetralin(1S,2R),D- ZINC3995702 2-Naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-1-methyl-N,N-dipropyl-, (1S-cis)- BRD-K66715657-001-01-3 QQYOR9S587 (+)-Uh 232 AC1O7GU2 CHEMBL278751 UH-232 [ Show all ]
Inchi Key	BTOJYCTUJJHANF-WMLDXEAASA-N
Inchi ID	InChI=1S/C18H29NO/c1-5-12-19(13-6-2)17-11-10-16-15(14(17)3)8-7-9-18(16)20-4/h7-9,14,17H,5-6,10-13H2,1-4H3/t14-,17+/m0/s1
PubChem CID	6604756
ChEMBL	CHEMBL278751
IUPHAR	N/A
BindingDB	50041961
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	48.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:5:689, Bioorg. Med. Chem. Lett., (1997) 7:21:2759, PMID8230107	BindingDB,ChEMBL

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