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GPCR

NameType-2 angiotensin II receptor
SpeciesRattus norvegicus (Rat)
GeneAgtr2
Synonymangiotensin II receptor, type 2
MRX88
Agtr2
AT2R
AT2-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length363
Amino acid sequenceMKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProtP35351
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL257
IUPHAR35
DrugBankN/A

Ligand

NameCHEMBL336808
Molecular formulaC29H34N4O2
IUPAC name2-[N-butyl-4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]anilino]-2-phenylacetic acid
Molecular weight470.617
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP6.6
SynonymsBDBM50043461
{Butyl-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-amino}-phenyl-acetic acid
Inchi KeyBTNFFZXSBQBCJY-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H34N4O2/c1-5-7-17-32(27(29(34)35)23-11-9-8-10-12-23)24-15-13-22(14-16-24)19-33-25(6-2)31-26-20(3)18-21(4)30-28(26)33/h8-16,18,27H,5-7,17,19H2,1-4H3,(H,34,35)
PubChem CID10434876
ChEMBLCHEMBL336808
IUPHARN/A
BindingDB50043461
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50660.0 nMPMID8277506ChEMBL
IC50660.0 nMPMID8277506BindingDB

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