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Name | Metabotropic glutamate receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm1 |
Synonym | mGluR1 SCAR13 mGlu1 receptor metabotropic glutamate receptor 1 wobl [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 1199 |
Amino acid sequence | MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL |
UniProt | P23385 |
Protein Data Bank | 1iss, 1isr, 1ewk |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 1iss. |
BioLiP | BL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4477 |
IUPHAR | 289 |
DrugBank | N/A |
Name | 61350-00-3 |
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Molecular formula | C12H9ClN2O |
IUPAC name | N-(3-chlorophenyl)pyridine-2-carboxamide |
Molecular weight | 232.667 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 2.6 |
Synonyms | VU 0364770 AKOS003020541 D0W9VN MolPort-002-826-420 VU0364770-1 [ Show all ] |
Inchi Key | SUYUTNCKIOLMAJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16) |
PubChem CID | 836002 |
ChEMBL | CHEMBL556667 |
IUPHAR | 6234 |
BindingDB | 50293743 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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EC50 | 1170.0 nM | PubChem BioAssay data set | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417