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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Homo sapiens (Human)
Gene	GRM4
Synonym	mGluR4 mGlu4 receptor GPRC1D glutamate receptor
Disease	Anxiety disorder Neurological disease
Length	912
Amino acid sequence	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProt	Q14833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T99402
ChEMBL	CHEMBL2736
IUPHAR	292
DrugBank	BE0000833

Ligand

Name	61350-00-3
Molecular formula	C12H9ClN2O
IUPAC name	N-(3-chlorophenyl)pyridine-2-carboxamide
Molecular weight	232.667
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.6
Synonyms	VU 0364770 AKOS003020541 D0W9VN MolPort-002-826-420 VU0364770-1 2565AH GTPL6234 N-(3-chlorophenyl)picolinamide SCHEMBL2530324 CS-6072 KB-276111 VU-0364770 BCP19097 DTXSID00356877 N-(3-chloro-phenyl)-pyridine-2-carboxamide N-(3-chlorophenyl)pyridine-2-carboxamide ZINC362766 CHEMBL556667 HMS3651P19 SW219537-1 AC1LHD0L CTK2E1861 KS-00001CNQ VU0364770 2-Pyridinecarboxamide, N-(3-chlorophenyl)- BDBM50293743 EX-A1099 N-(3-chlorophenyl)-2-pyridinecarboxamide s2862 cid_836002 HY-100588 [ Show all ]
Inchi Key	SUYUTNCKIOLMAJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
PubChem CID	836002
ChEMBL	CHEMBL556667
IUPHAR	6234
BindingDB	50293743
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1090.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
EC50	1100.0 nM	PMID19469556, PMID22088953	BindingDB,IUPHAR,ChEMBL
EC50	1196.0 nM	PMID26231155	BindingDB,ChEMBL
Emax	227.0 %	PMID19469556	ChEMBL
FC	18.1 -	PMID19469556	ChEMBL

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