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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3641692
Molecular formula	C17H22N4O3
IUPAC name	5-(2-methoxyethoxy)-N-[4-[(2S)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight	330.388
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	0.9
Synonyms	BDBM129496 SCHEMBL12609790 US8802673, 138
Inchi Key	BTISYLVPHUYZBS-MRXNPFEDSA-N
Inchi ID	InChI=1S/C17H22N4O3/c1-22-8-9-23-15-10-19-17(20-11-15)21-14-4-2-13(3-5-14)16-12-18-6-7-24-16/h2-5,10-11,16,18H,6-9,12H2,1H3,(H,19,20,21)/t16-/m1/s1
PubChem CID	68325562
ChEMBL	CHEMBL3641692
IUPHAR	N/A
BindingDB	129496
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	64.1 nM	, None	BindingDB,ChEMBL

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