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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	Clorgiline
Molecular formula	C13H15Cl2NO
IUPAC name	3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine
Molecular weight	272.169
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.2
Synonyms	LS-125796 n-methyl-n-propargyl-3-(2,4-dichlorophenoxy)propylamine NCGC00162235-01 UNII-LYJ16FZU9Q 2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-(9CI) BRD-K73251053-003-03-2 CHEBI:3763 D09QDP M and B 9302 N-[3-(2,4-dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine Prestwick2_000344 [3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynyl-propan-1-amine BSPBio_000407 Chlorgyline Clorgiline [INN] GTPL6636 N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propynylamine NCGC00015669-03 SCHEMBL61914 2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl- BDBM15581 CAS-17780-75-5 Clorgilina CLORGYLINE Lopac-M-3778 LYJ16FZU9Q N-[3-(2,4-DICHLOROPHENOXY)PROPYL]-N-METHYL-N-PROP-2-YNYLAMINE Prestwick0_000344 US8633208, Clorgyline 2-Propyn-1-amine, N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-, hydrochloride BRD-K73251053-003-13-1 Clorgiline (INN) DB04017 M&B 9302 NCGC00015669-01 Prestwick3_000344 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine BTFHLQRNAMSNLC-UHFFFAOYSA-N CLG Clorgilinum KB-76141 Lopac0_000746 N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine NCGC00015669-04 SPBio_002328 2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl- (9CI) BPBio1_000449 CCG-204831 Clorgilina [INN-Spanish] D03248 M & B 9302 N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine Prestwick1_000344 ZINC22200090 2-Propynylamine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl- BRN 1976758 CHEMBL8706 Clorgiline [INN:BAN] DTXSID3048445 M&B-9302 NCGC00015669-02 SBI-0050724.P002 17780-72-2 AC1L1I1A C11685 Clorgilin Clorgilinum [INN-Latin] L001342 [ Show all ]
Inchi Key	BTFHLQRNAMSNLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
PubChem CID	4380
ChEMBL	CHEMBL8706
IUPHAR	N/A
BindingDB	15581
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1000.0 nM	PMID8876023	BindingDB

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