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GPCR

Name5-hydroxytryptamine receptor 5A
SpeciesMus musculus (Mouse)
GeneHtr5a
SynonymMR22
Htr5
5HT5-
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
5-HT5alpha
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProtP30966
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3597
IUPHAR10
DrugBankN/A

Ligand

NameCHEMBL129163
Molecular formulaC21H22N2O
IUPAC name1-phenyl-4-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)butan-1-one
Molecular weight318.42
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP3.6
SynonymsBDBM50132112
1-Phenyl-4-(1,3,4,9-tetrahydro-beta-carbolin-2-yl)-butan-1-one
Inchi KeySJUGUCWHNWWFDF-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H22N2O/c24-21(16-7-2-1-3-8-16)11-6-13-23-14-12-18-17-9-4-5-10-19(17)22-20(18)15-23/h1-5,7-10,22H,6,11-15H2
PubChem CID11045379
ChEMBLCHEMBL129163
IUPHARN/A
BindingDB50132112
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki550.0 nMPMID12930153BindingDB,ChEMBL

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