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GLASS

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GPCR

Name	Metabotropic glutamate receptor 4
Species	Homo sapiens (Human)
Gene	GRM4
Synonym	mGluR4 mGlu4 receptor GPRC1D glutamate receptor
Disease	Anxiety disorder Neurological disease
Length	912
Amino acid sequence	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProt	Q14833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T99402
ChEMBL	CHEMBL2736
IUPHAR	292
DrugBank	BE0000833

Ligand

Name	SIB 1893
Molecular formula	C14H13N
IUPAC name	2-methyl-6-[(E)-2-phenylethenyl]pyridine
Molecular weight	195.265
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	3.6
Synonyms	SIB-1893 [E]-2-Methyl-6-[2-phenylethenyl]pyridine (E)-2-Methyl-6-[2-phenylethenyl]pyridine 6266-99-5 BRD-K67439147-001-01-7 HMS3263L03 MolPort-003-959-634 NSC36665 PDSP2_001555 SR-01000076143 2-methyl-6-(2-phenylethenyl)pyridine AC1Q4VO3 CHEBI:93178 L000561 NCGC00025046-04 Tox21_501171 (E)-2-Methyl-6-(2-phenylethyl)-pyridine 2-[(E)-Styryl]-6-methylpyridine BDBM50084141 EU-0101171 MFCD02262120 NCGC00261856-01 SIB1893 7370-21-0 CAS_5311432 KB-231610 NCGC00025046-02 NSC_5311432 Pyridine,2-methyl-6-(2-phenylethenyl)- SR-01000076143-1 2-Methyl-6-styryl-pyridine(SIB-1893) AKOS006279967 Lopac0_001171 NCGC00025046-05 SIB 1893, >99%, solid ZINC3941522 (E)-2-methyl-6-styrylpyridine BDBM86715 GTPL1432 MLS002607995 NSC-36665 PDSP1_001571 SMR000326914 2-Methyl-6-((E)-styryl)-pyridine AC1NSKMI CCG-205245 KB-60434 NCGC00025046-03 S 9311 SR-01000076143-3 2-methyl-6-[(E)-2-phenylethenyl]pyridine BC600133 CHEMBL88612 LP01171 NCGC00025046-06 [ Show all ]
Inchi Key	SISOFUCTXZKSOQ-ZHACJKMWSA-N
Inchi ID	InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
PubChem CID	5311432
ChEMBL	CHEMBL88612
IUPHAR	1432
BindingDB	50084141
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	150.0 - 470.0 nM	PMID12684257	IUPHAR
Ki	26000.0 nM	PMID10893301	BindingDB,ChEMBL

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