Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Retinoic acid-induced protein 3
Species	Homo sapiens (Human)
Gene	GPRC5A
Synonym	Retinoic acid-induced gene 1 protein retinoic acid induced 3 RAIG1 RAIG-1 RAI3 Phorbol ester induced gene 1 {ECO:0000303\|PubMed:8832110} PEIG-1 orphan G protein-coupling receptor PEIG-1 GPRC5A GPCR5A G-protein coupled receptor family C group 5 member A G protein-coupled receptor, class C, group 5, member A G protein-coupled receptor Retinoic acid-induced protein 3 [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
UniProt	Q8NFJ5
Protein Data Bank	N/A
GPCR-HGmod model	Q8NFJ5
3D structure model	This predicted structure model is from GPCR-EXP Q8NFJ5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	BE0000697

Ligand

Name	Retinoic acid
Molecular formula	C20H28O2
IUPAC name	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Molecular weight	300.442
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.3
Synonyms	3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid-, (all trans)- all-trans-beta-Retinoic acid Tretinoinum 33998-EP2275420A1 Alltrans-retinoic acid Vesanoid (TN) (Roche) 33998-EP2298768A1 Salt, Tretinoin Zinc Atralin WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U1VQ C1 C1 33998-EP2311840A1 SMR000058245 BCP01405 9-cis-RA SR-01000000239-14 Betarretin AB00052318-16 Stieva-A Aberela (TN) Tox21_501061 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid Acid, Retinoic Tretinoin (JAN/USP/INN) 02T794 AGN 100335 Tretinoin Zinc Salt 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)--, (all trans)- All Trans Retinoic Acid Tretinoina IDI1_000903 Retinoic acid, all-trans- LMPR01090019 RP17637 MLS002222211 BPBio1_000082 NCGC00017280-08 C00777 NCGC00017280-19 cis-Retinoic acid NCGC00021808-11 NSC-122758 EINECS 206-129-0 Prestwick2_000257 HMS1791K22 REA HMS3263E04 Retin-A Tretinoine (French) 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid all-trans-retinoic acid (ATRA) Tri-Luma 33998-EP2295426A1 ARONIS25153 Vitamin A acid 33998-EP2308833A2 SBI-0051031.P003 Avita Gel [3H]RA 5688UTC01R Spectrum5_001746 beta all trans Retinoic Acid 97950-17-9 SR-01000000239-4 BML2-E05 AB00052318_19 TNP00194 (2E,4E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraenoic acid AC1L9GWO trans-Retinoic acid (9Z,13Z)-Retinoic acid acide retinoique (French) Tretinoin - Retinoic Acid 187175-63-9 AJ-61307 Tretinoin, all-trans- 2,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)- all-(E)-Retinoic acid Isotretinoin Retinoicacid Retinoic acid, cis- LS-1154 MolPort-000-883-857 BRD-K71879491-001-15-0 NCGC00017280-12 CCRIS 3294 NCGC00021808-04 CPD000058245 NCGC00254179-01 DSSTox_GSID_21239 NSC759631 Eudyna PubChem16466 HMS2089D20 Renova (0.02% cream) HMS502N05 Retinoate all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid Tretinoino 302-79-4 all-trans-Vitamin A acid Vesanoid 33998-EP2298764A1 Salt, Tretinoin Potassium ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid Vitamin A1 acid, all-trans- 33998-EP2311808A1 SCHEMBL3145 b-Retinoic acid [3H]Vitamin A acid 6-s-trans-retinoic acid SR-01000000239-12 beta-Retinoate A-Vitaminsyre [Denmark] ST057075 Aberel Tox21_202330 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aenoic acid Acid, all-trans-Retinoic Tretin M .beta.-all-trans-Retinoic acid Acnavit [Denmark] Tretinoin Potassium Salt 2,4, 6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6, 6-trimethyl-1-cyclohexen-1-yl)-, (2E, 4E, 6E, 8E)- Aknoten Tretinoin, United States Pharmacopeia (USP) Reference Standard 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate Retinoic acid, >=98% (HPLC), powder KB-66303 Retisol-A MLS001076515 NCGC00017280-06 BSPBio_000074 NCGC00017280-17 CHEMBL38 NCGC00021808-07 D02DGU Nexret Effederm Pharmakon1600-01502016 HMS1361K22 R 2625 HMS2236N03 Retin A I04-0008 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid all-trans-Retinoate Tretinoinum [INN-Latin] 33998-EP2295055A2 Altreno (0.05% lotion) Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Tretinoin 33998-EP2301928A1 SAM002264647 Avita (0.025% gel) Zinc Salt, Tretinoin 4759-48-2 Sodium Salt, Tretinoin BCPP000036 9-cis-retinoic acid (9cRA) SR-01000000239-15 BIDD:GT0483 AB00052318-17 Stieva-A (TN) Aberela [Norway] trans Retinoic Acid (4E,6E,8E)-9-(2,6,6-Trimethyl-1-cyclohexenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid Acid, trans-Retinoic Tretinoin (Retinoic acid) 13497-05-7 (hydrochloride salt) AGN100335 Tretinoin [USAN:INN:BAN] 2,4,6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)- all trans-Retinoic acid Tretinoina [INN-Spanish] IDI1_033970 Retinoic acid, all-trans- (8CI) Lopac0_001061 S-1635 MLS002548861 BR-73126 NCGC00017280-09 CAS-302-79-4 NCGC00017280-20 Cordes vas NCGC00021808-14 Dermairol NSC-759631 Epi-aberel Prestwick3_000257 HMS1921D14 Refissa HMS3402K22 Retin-A (TN) All-trans Retinoic Acid tretinoine (French) (EINECS) 3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid all-trans-Retinoic acid, 97% UNII-5688UTC01R 33998-EP2295427A1 AT-RA Vitamin A acid, all-trans- 33998-EP2308861A1 SC-16932 Avitoin [3H]Retinoic acid 5914-EP2275412A1 Spectrum5_001933 beta-all-trans-Retinoic acid A-Acido (Argentina) SR-01000000239-6 bmse000562 AB03039 Tox21_110812 (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid AC1Q1J2J trans-Retinoic acid\|\|\|Retinoid analogues (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate Acide retinoique (French) (DSL) Tretinoin 0.1% cream or placebo 1cbr AK-73126 Tretinoin, European Pharmacopoeia (EP) Reference Standard 2,6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)- Isotretinoin;(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid Retinova MFCD00001551 NC00481 BRD-K71879491-001-22-6 NCGC00017280-15 CHEBI:15367 NCGC00021808-05 CS-1269 NCGC00259879-01 DSSTox_RID_76031 Opera_ID_1055 GS-3578 Q-200610 HMS2092N11 Renova (TN) HSDB 2169 all-trans-b-Retinoic acid Tretinoino [INN-Spanish] all-trans-Vitamin A1 acid Vesanoid (TN) 33998-EP2298765A1 Salt, Tretinoin Sodium Atragen WLN: L6UTJ A1 B1U1Y1 & U2U1Y1 & U1VQ C1 C1 33998-EP2311829A1 SHGAZHPCJJPHSC-YCNIQYBTSA-N BC202905 [All-E]-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid 7005-78-9 SR-01000000239-13 beta-Retinoic acid AB00052318-15 ST2407905 Aberela Tox21_300305 (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid Acid, beta-all-trans-Retinoic tretinoin .beta.-Retinoic acid ACT00012 Tretinoin Sodium Salt 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)- AKOS000280845 Tretinoin/All-Trans Retinoic Acid 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid RETINOIC ACID, ALL TRANS L000833 Ro 1-5488 MLS002207234 BP-20401 NCGC00017280-07 BSPBio_001500 NCGC00017280-18 cid_444795 NCGC00021808-09 D0A8ND NSC 122758 Effederm [France] Potassium Salt, Tretinoin HMS1568D16 R0064 HMS3259E11 Retin A (TN) I14-2351 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL) all-trans-Retinoic acid TRETINON 33998-EP2295416A2 AN-9660 Vesnaroid 33998-EP2305642A2 SBB065722 Avita (TN) ZINC12358651 56573-65-0 SPECTRUM1502016 BDBM31883 9-trans-retinoic acid SR-01000000239-3 BIDD:PXR0081 AB00052318_18 SW203749-4 (11Z)-retinoic acid AC-6824 trans-Retinoate (5E)-Retinoic acid Acid, Vitamin A Tretinoin (TN) 15-Apo-beta-caroten-15-oic acid Airol Tretinoin [USAN:USP:INN:BAN] 2,4,6,8-Nonatetranoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all trans)- all-(E)-Retinoate Tretinoine ISORETINOIN Retinoic acid, all-trans-(8CI) LP01061 MLS006010222 BRD-K06926592-001-01-7 NCGC00017280-10 CCG-39912 NCGC00017280-23 Cordes VAS [Germany] NCGC00021808-15 DSSTox_CID_1239 NSC122758 EU-0101061 Prestwick_424 HMS1989K22 Renova HMS3712D16 Retin-A Micro All-trans Retinoic Acid (Tretinoin) Tretinoine [INN-French] 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acid all-trans-Tretinoin UPCMLD-DP097 33998-EP2298748A2 s1653 ATRA Vitamin a acid, trans- 33998-EP2311453A1 SCHEMBL19091395 Avitoin [Norway] [3H]tretinoin 5914-EP2292576A2 SR-01000000239 beta-Ra A-Vitaminsyre SR-01000000239-7 AB1009361 Tox21_110812_1 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid Acid A Vit (Belgium, Netherlands) Trans-Retinoicacid (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid Acnavit tretinoin liposome 1n4h Aknefug Tretinoin, Pharmaceutical Secondary Standard; Certified Reference Material 3,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid Retinoic acid all trans J10054 Retionic acid MLS000028588 NCGC00017280-05 BRN 2057223 NCGC00017280-16 NCGC00021808-06 D00094 NCGC00261746-01 DTXSID7021239 PDT-002-002 GTPL2644 QCR-120 HMS2095D16 Retacnyl HY-14649 [ Show all ]
Inchi Key	SHGAZHPCJJPHSC-YCNIQYBTSA-N
Inchi ID	InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
PubChem CID	444795
ChEMBL	CHEMBL38
IUPHAR	N/A
BindingDB	31883
DrugBank	DB00755
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417