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GPCR

Name	Kappa-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRK1
Synonym	K-OR-1 KOPr OP2 KOP KOR-1 Kappa receptor [ Show all ]
Disease	Obesity Opiate dependence Inflammatory bowel disease Erythema Diarrhea-predominant IBS Unspecified Bipolar disorder Alcohol use disorders Pain Substance dependence Neurodegenerative disease [ Show all ]
Length	380
Amino acid sequence	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
UniProt	P41145
Protein Data Bank	6b73, 4djh
GPCR-HGmod model	P41145
3D structure model	This structure is from PDB ID 6b73.
BioLiP	BL0402244,BL0402246, BL0224693,BL0224694, BL0402243,BL0402245
Therapeutic Target Database	T60693
ChEMBL	CHEMBL237
IUPHAR	318
DrugBank	BE0000632

Ligand

Name	oxycodone
Molecular formula	C18H21NO4
IUPAC name	(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular weight	315.369
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.2
Synonyms	Oxycodeinon 4aH-8,5-bcd]furan-5(6H)-one, 7,7a,8,9-tetrahydro-7a-hydroxy-3-methoxy-12-methyl- Oxycodone Hcl Apo-oxycodone CR Oxycone Pancodone Retard D05312 PF06 Dihydrohydroxycondeinone Supendol [Canada] Endocet (TN) Tylox (TN) Eutagen Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- (8CI) Ossicodone [DCIT] (5alpha)-14-hydroxy-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one 76-42-6 Oxycodone [USAN:INN:BAN] BRN 0043446 Oxyfast Codeinone, dihydro-14-hydroxy- Percocet (TN) Roxicet (TN) Dinarkon Tekodin Eubine Xtampza Hydroxycodeinon Morphinan-6-one,5.alpha.-epoxy-14-hydroxy-3-methoxy-17-methyl- Oxicodona [INN-Spanish] 14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one 4,5.alpha.-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone 1.0 mg/ml in Methanol AKOS015962233 Oxycodonum [INN-Latin] CD35PMG570 Oxynorm Combunox (TN) Percolone Dihydro-14-hydroxycodeinone SCHEMBL2737 EINECS 200-960-2 Thekodin Eucodalum Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)- NSC19043 (1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0;{1,13}.0;{5,17}.0;{7,18}]octadeca-7(18),8,10-trien-14-one Oxiconum Oxycodeinone Oxycodone hydrochloride Avridi Oxycontin CHEMBL656 Pancodone retard (United Kingdom) D0J0TD PTI-821 Dihydrone Supeudol Endodan (TN) UNII-CD35PMG570 GTPL7093 Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-(8CI) Oxanest 124-90-3 Oxycodone (USAN/INN) AC-16043 Oxycodone/ naloxone controlled release BRUQQQPBMZOVGD-XFKAJCMBSA-N OxyIR Codeinone, dihydrohydroxy- Percodan DB00497 Roxicodone Diphydrone Tekodin (free base) Eubine [France] Xtampza ER LS-92148 NSC 19043 (-)-14-Hydroxydihydrocodeinone Oxicon 14-Hydroxydihydrocodeinone 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone Concentrate AN-22961 Oxycon CHEBI:7852 Pancodine D03SKD PF-00345439 Dihydrohydroxycodeinone Supendol Endine (Australia) Theocodin Eukodal Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- Ossicodone (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Oxikon Oxycodon 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine Oxycodone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material BDBM50370595 Oxycontin (TN) Codeinone, 7,8-dihydro-14-hydroxy- Percobarb D0P6KE Remoxy Dihydroxycodeinone Tecodin Endone WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JO1 P1 HSDB 3142 Morphinan-6-one,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5.alpha.)- Oxicodona 124-90-3 (hydrochloride) 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Oxycodone 0.1 mg/ml in Methanol AC1Q4DTG Oxycodonum C08018 Oxyneo Codeinone,8-dihydro-14-hydroxy- Percodan (TN) DEA No. 9143 Roxiprin (TN) DTXSID5023407 Thecodine Eucodal ZINC403533 Morphinan-6-one, 4,5-alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- NSC-19043 (-)-Oxycodone Oxicone [ Show all ]
Inchi Key	BRUQQQPBMZOVGD-XFKAJCMBSA-N
Inchi ID	InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
PubChem CID	5284603
ChEMBL	CHEMBL656
IUPHAR	N/A
BindingDB	50370595
DrugBank	DB00497
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	16000.0 nM	PMID23880538	ChEMBL
Inhibition	47.0 %	PMID23880538	ChEMBL

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