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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	norepinephrine
Molecular formula	C8H11NO3
IUPAC name	4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	EINECS 200-096-6 4786-EP2270011A1 HMS2091J08 4786-EP2305644A1 KBio2_004057 4786-EP2314571A2 L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol AB00052424-06 AKOS015854572 (-)-Arterenol free base Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (+)- (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol CAS-51-41-2 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- D-(-)-Noradrenaline 21779-EP2272847A1 DB00368 21779-EP2311828A1 PDSP2_001095 SGCUT00123 Spectrum_001009 W-105896 Levonor NCGC00159406-03 NCGC00159406-11 Noradrenalin, l- Noreinefrina Norepinephrine [INN:BAN:JAN] FT-0658803 4786-EP2287163A1 HY-13715 4786-EP2305678A1 KBioGR_000635 L-Norepinephrine AC1L96ZT (+)-Noradrenaline AN-24392 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2-?amino-?1-?hydroxyethyl]?- BRN 4231961 (R)-Noradrenaline CHEBI:18357 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI) D00076 21779-EP2287166A2 DSSTox_CID_3378 21779-EP2377510A1 Norepinephrinum [INN-Latin] R-norepinephrine SPECTRUM1500436 Tox21_301944 ZINC57624 Levophed NCGC00159406-06 Nor adrenalin noradrenaline NOREPINEPHIRINE 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol HMS1920B08 4786-EP2292620A2 KBio1_000230 4786-EP2308875A1 l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol 51-41-2 AJ-09755 (-)-alpha-(Aminomethyl)protocatechuyl alcohol Arterenol (R)-( C)-Norepinephrine C-4015 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)- CS-0007744 138-65-8 D53D5E3A-2360-4CA9-8031-6C2CD4062FD5 21779-EP2298742A1 DTXSID5023378 NSC757246 SCHEMBL2609 Spectrum4_000078 UNII-K294OAI79V component SFLSHLFXELFNJZ-QMMMGPOBSA-N Levarterenolo [DCIT] MFCD00025592 NCGC00159406-09 Nor-Epirenan Noradrenalinum Norepinephrine l-Tartrate (1:1) FCH920095 4786-EP2280010A2 HMS500L12 4786-EP2305648A1 KBio2_006625 4786-EP2316836A1 L-arterenol AB00052424_07 Aktamin (-)-NORADRENALINE Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol CC-33071 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI) d-Arterenol 21779-EP2284170A1 DermX 21779-EP2311835A1 Pharmakon1600-01500436 SMR000058585 STK503776 X4W3ENH1CV Levonoradrenaline NCGC00159406-04 NCGC00255328-01 Noradrenalina Noreinefrina [INN-Spanish] Norepinephrine [INN:JAN] 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol FT-0679201 4786-EP2287165A2 I01-15661 4786-EP2308864A1 KBioSS_001489 Levarterenol Adrenaline Impurity (+)-Norepinephrine ANW-74377 (-)-Norepinephrine BSPBio_002079 (R)-Norepinephrine 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- D07MOX 21779-EP2292620A2 DSSTox_GSID_23378 Norepirenamine SBI-0050082.P003 Spectrum2_001064 to_000024 LS-42676 NCGC00159406-07 Nor adrenalin (TN) Noradrenaline (JP15) 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol HMS2089E18 4786-EP2298776A1 KBio2_001489 4786-EP2311831A1 L-3,4-dihydroxyphenylethanolamine 66197-73-7 AKOS006345192 (-)-Arterenol BDBM50029051 (R)-(-)-Norepinephrine C00547 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- CTK4C1344 21779-EP2269990A1 21779-EP2305669A1 Ecteinascidins PDSP1_001111 SFLSHLFXELFNJZ-QMMMGPOBSA-N Spectrum5_001068 UNII-X4W3ENH1CV Levoarterenol MLS006010883 NCGC00159406-10 Noradrenalin Norartrinal Norepinephrine Noradrenalin FT-0603221 4786-EP2284171A1 HSDB 7772 4786-EP2305677A1 KBio3_001579 4899-05-2 L-Noradrenaline AB00052424_08 ALBB-006229 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2 bmse000404 (R)-4-(2-Amino-1-hydroxyethyl)catechol CCG-40104 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- d-Norepinephrine 21779-EP2287165A2 DivK1c_000230 21779-EP2314571A2 PubChem6074 SPBio_001048 Sympathin E xi-Norepinephrine Levonorepinephrine NCGC00159406-05 NINDS_000230 Noradrenalina [Italian] norepinefrina norepinephrinum 4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol GTPL505 4786-EP2287166A2 IDI1_000230 4786-EP2308873A1 l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol 51-40-1 (l-tartrate (1:1)) Levarterenolo Adrenor (-)-(R)-Norepinephrine API0003193 (-)-Norepinephrine, >=98%, crystalline C-05156 025N592 CHEMBL1437 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)- D0R2UN 21779-EP2298731A1 DSSTox_RID_77004 NSC-757246 SC-04955 Spectrum3_000520 TR-005105 LT03330026 NCGC00159406-08 Nor-adrenaline Noradrenaline (JP17) Norepinephrine (INN) [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID	439260
ChEMBL	CHEMBL1437
IUPHAR	505
BindingDB	50029051
DrugBank	DB00368
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	61.66 nM	PMID15566287, PMID18578476, PMID17630725	ChEMBL
EC50	62.0 nM	PMID18578476, PMID17630725	BindingDB
Intrinsic activity	1.0 -	PMID15566287, PMID19886609	ChEMBL
Ki	1000.0 - 3981.07 nM	PMID9824686, PMID9605427	IUPHAR

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