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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Galr2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A for non-human GPCRs
Length	372
Amino acid sequence	MNGSGSQGAENTSQEGGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDLCTFVFSYLLPVLVLSLTYARTLRYLWRTVDPVTAGSGSQRAKRKVTRMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQVSEAAGPLVPPPALPNCTASSRTLDPAC
UniProt	O08726
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5577
IUPHAR	244
DrugBank	N/A

Ligand

Name	ALX-1393
Molecular formula	C23H22FNO4
IUPAC name	(2S)-2-amino-3-[(3-fluorophenyl)-(2-phenylmethoxyphenyl)methoxy]propanoic acid
Molecular weight	395.43
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.2
Synonyms	GTPL4622 O-[2-benzyloxyphenyl-3-flurophenyl]methyl-L-serine BDBM50256745 CTK8F7695 NCGC00165720-01 ALX-1393, >98% (HPLC), powder (2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophenyl)methoxy)propanoic acid ALX 1393 D0E1OC O-[(2-Benzyloxyphenyl-3-flurophenyl)methyl]-L-serine ALX1393 (2S)-2-amino-3-{[2-(benzyloxy)phenyl](3-fluorophenyl)methoxy}propanoic acid CHEMBL475562 [ Show all ]
Inchi Key	ADUSZEGHFWRTQS-AIBWNMTMSA-N
Inchi ID	InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1
PubChem CID	16078939
ChEMBL	CHEMBL475562
IUPHAR	N/A
BindingDB	50256745
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	21.1 nM	PMID19013063	BindingDB,ChEMBL

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