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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	CHEMBL6310
Molecular formula	C12H14N2O
IUPAC name	7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Molecular weight	202.257
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.5
Synonyms	AKOS004119616 7-Methoxy-1,2,3,4-tetrahydro-beta-carboline 91566-22-2 SCIRNASYBOGBOO-UHFFFAOYSA-N BDBM50132097 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline D05GDP AC1LCCZT ZINC13587968 7-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole 7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Methyl 2,3,4,9-tetrahydro-1H-beta-carbolin-7-yl ether # [ Show all ]
Inchi Key	SCIRNASYBOGBOO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H14N2O/c1-15-8-2-3-9-10-4-5-13-7-12(10)14-11(9)6-8/h2-3,6,13-14H,4-5,7H2,1H3
PubChem CID	599482
ChEMBL	CHEMBL6310
IUPHAR	N/A
BindingDB	50132097
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	140.0 nM	PMID14643338	BindingDB,ChEMBL

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