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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Mus musculus (Mouse)
Gene	Htr1d
Synonym	HTRL Htr1db HT1DA Gpcr14 5-HT-1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 5-HT1Dalpha 5-HT1D receptor 5-HT1D serotonin receptor 1D [ Show all ]
Disease	N/A for non-human GPCRs
Length	374
Amino acid sequence	MSPPNQSLEGLPQEASNRSLNVTGAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKIS
UniProt	Q61224
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4297
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	WAY-100635
Molecular formula	C25H34N4O2
IUPAC name	N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide
Molecular weight	422.573
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.2
Synonyms	HY-10349 N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide NSC_104911 WAY 100,635 ZINC52541473 71IH826FEG BDBM86708 Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-, hydrochloride Lopac-W-108 NCGC00016092-01 Rec 0/0277 WAY-100,635 146714-97-8 A3933 CHEBI:125619 DTXSID20167467 GTPL3251 n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-cyclohexanecarboxamide NCGC00016092-13 UNII-71IH826FEG WAY100635 2799AH AC1Q5IB0 CS-0418 KB-81480 N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide-Tritiated PDSP1_001716 Way 100635 [3H]WAY100635 CAS_146714-97-8 D07BCO EX-A1053 Lopac0_001229 NCGC00016092-02 SB19513 162760-96-5 ABP000343 GTPL80 N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-CYCLOHEXANECARBOXAMIDE TRIHYDROCHLORIDE NCGC00162372-01 W-5217 X7593 AKOS027313833 cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl- L000012 N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide PDSP2_001699 WAY 100635;WAY100635 CCG-205303 D08WYI FT-0728251 LS-56585 NCGC00016092-03 SCHEMBL84178 WAY-100635 maleate salt/ 162760-96-5, WAY100635, WAY 100635 AC1L1KWK CHEMBL31354 [ Show all ]
Inchi Key	SBPRIAGPYFYCRT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3
PubChem CID	5684
ChEMBL	CHEMBL31354
IUPHAR	80, 3251
BindingDB	86708
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.34 nM	PMID10229627	ChEMBL
Ki	0.34 nM	PMID10229627	BindingDB
Ki	1.09 nM	PMID10229627	ChEMBL
Ki	1.1 nM	PMID10229627	BindingDB

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