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Name | D(2) dopamine receptor |
---|---|
Species | Bos taurus (Bovine) |
Gene | DRD2 |
Synonym | Dopamine D2 receptor |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P20288 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3998 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL545203 |
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Molecular formula | C13H18ClNO2 |
IUPAC name | 6-[2-chloroethyl(methyl)amino]-5,6,7,8-tetrahydronaphthalene-2,3-diol |
Molecular weight | 255.742 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 2.6 |
Synonyms | BDBM50024702 CHEMBL1193741 6-[(2-Chloro-ethyl)-methyl-amino]-5,6,7,8-tetrahydro-naphthalene-2,3-diol; hydrochloride |
Inchi Key | BQKCJCQWIPRWQF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C13H18ClNO2/c1-15(5-4-14)11-3-2-9-7-12(16)13(17)8-10(9)6-11/h7-8,11,16-17H,2-6H2,1H3 |
PubChem CID | 13897477 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50024702 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1820.0 nM | PMID3656361 | BindingDB |
IC50 | 3720.0 nM | PMID3656361 | BindingDB |
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