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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	Oxotremorine
Molecular formula	C12H18N2O
IUPAC name	1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one
Molecular weight	206.289
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	0.4
Synonyms	BRN 1530948 CHEMBL7634 FT-0631303 KBio2_001928 KBioSS_001928 NCGC00015773-02 NSC 330497 SCHEMBL2128 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one Spectrum_001448 AB00053670-07 C07485 D08FOC HMS2089F17 KBio2_004961 Lopac-O-9126 NCGC00015773-05 Oxotremorin Spectrum2_001568 2'-Oxopyrrolidino-1-pyrrolidino-4-butyne Tocris-0843 WLN: T5NVTJ A2UU2- AT5NTJ BDBM50004665 CHEBI:7851 DTXSID10220252 IDI1_000410 KBio3_002698 MLS000766260 NCGC00024821-03 Oxytremorine 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one (oxotremorphine) Spectrum5_001099 2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]- BSPBio_003198 cid_4630 Green tea KBio2_002393 KBioSS_002398 NCGC00015773-03 NSC-330497 SMR000528860 1-(4-pyrrolidino-2-butynyl)-2-pyrrolidinone Spectrum_001875 5RY0UWH1JL AC1L1ILJ CC-33422 D0L1XR HMS2231C13 KBio2_007064 Lopac0_000914 NCGC00024821-01 1-(4-(Pyrrolidin-1-yl)but-2-ynyl)pyrrolidin-2-one Spectrum3_001599 2-PYRROLIDINONE, 1-(4-(1-PYRROLIDINYL)-2-BUTYNYL)- Tremorine, oxo- ZINC1530795 BRD-K21936341-051-02-4 EINECS 200-728-0 KBio1_000410 KBioGR_001404 NCGC00015773-01 NINDS_000410 RSDOPYMFZBJHRL-UHFFFAOYSA-N 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one(Oxotremorine) Spectrum5_001686 C-29897 CTK5D2064 GTPL302 KBio2_004496 L001302 NCGC00015773-04 NSC330497 (oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one SPBio_001476 1-[4-(2-oxo-pyrrolidin-1-yl)-but-2-ynyl]-pyrrolidinium SR-01000075154-3 70-22-4 AC1Q6LI4 CCG-204996 DivK1c_000410 HMS3372G17 KBio2_007529 LS-139008 NCGC00024821-02 Oxotremorine1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one 1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one Spectrum4_000912 2-Pyrrolidinone, 1-[4-(1-pyrrolidinyl)-2-butynyl]- UNII-5RY0UWH1JL [ Show all ]
Inchi Key	RSDOPYMFZBJHRL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
PubChem CID	4630
ChEMBL	CHEMBL7634
IUPHAR	302
BindingDB	50004665
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	55.0 nM	PMID7783150	ChEMBL
EC50	55.0 nM	PMID7783150	BindingDB
Efficacy	82.8 %	PMID25765911	ChEMBL
IC50	8000.0 nM	PMID9438027	BindingDB,ChEMBL

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