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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesMus musculus (Mouse)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProtP30557
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4336
IUPHAR342
DrugBankN/A

Ligand

NameCHEMBL362541
Molecular formulaC23H25NO5
IUPAC name2-[1-(4-butoxybenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Molecular weight395.455
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.9
Synonyms[1-(4-Butoxy-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid
BDBM50150973
SCHEMBL18271385
Inchi KeyROFCWYRMFXUFSI-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H25NO5/c1-4-5-12-29-17-8-6-16(7-9-17)23(27)24-15(2)19(14-22(25)26)20-13-18(28-3)10-11-21(20)24/h6-11,13H,4-5,12,14H2,1-3H3,(H,25,26)
PubChem CID11395329
ChEMBLCHEMBL362541
IUPHARN/A
BindingDB50150973
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID15357992BindingDB,ChEMBL

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