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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	pirenzepine
Molecular formula	C19H21N5O2
IUPAC name	11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Molecular weight	351.41
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	0.1
Synonyms	PDSP2_000949 AB00053603 pirenzepinedihydrochloride BPBio1_000196 RMHMFHUVIITRHF-UHFFFAOYSA-N CAS-28797-61-7 Spectrum4_000437 D08389 ZINC19632927 DTXSID7023487 HMS2089K21 KBioSS_001858 NCGC00015836-01 11-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one NCGC00015836-09 NCGC00024297-02 5,11-Dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one Pirenzepina [INN-Spanish] AC1L1J3B Prestwick0_000129 BRN 0628987 SMR000058502 CHEBI:8247 Tocris-1071 DB00670 Gasteril KBio2_001858 Lopac-P-7412 NCGC00015836-04 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride 2-[2-(4-methylpiperazin-1-yl)acetyl]-2,4,9-triazatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one NINDS_000127 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]- Pirenzepine Gastrozepin BCP12188 Prestwick3_000129 C07508 Spectrum2_001417 cid_185248 Ulcosan DSSTox_GSID_23487 Gastrozepin (TN) KBio3_002445 LS-519 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one NCGC00015836-07 NCGC00015836-10 Pirenzepin AB00053603-08 Pirenzepinum BRD-K89375097-300-05-4 SBI-0050935.P003 CAS-29868-97-1 Spectrum5_001344 D0T0LM EINECS 249-228-4 IDI1_000127 L-S 519 NCGC00015836-02 11-[2-(4-methylpiperazin-1-yl)-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one NCGC00024297-04 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one AKOS015969751 Prestwick1_000129 BSPBio_000178 SPBio_001494 Tox21_110239 DivK1c_000127 Gastrotsepin KBio2_004426 Lopac0_000962 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one NCGC00015836-05 11-[2-(4-methylpiperazin-1-yl)ethanoyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride 28797-61-7 PDSP1_000965 97P617 Pirenzepine [INN:BAN] BDBM39341 Pyrenzepine C19H21N5O2 Spectrum3_001453 CTK6I3129 UNII-3G0285N20N DSSTox_RID_77049 GTPL328 KBioGR_000794 MLS000069702 11-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride NCGC00015836-08 NCGC00015836-12 3G0285N20N Pirenzepina AB00053603_09 Pirenzepinum [INN-Latin] BRD-K89375097-300-06-2 SCHEMBL41705 CCG-205042 Spectrum_001378 FT-0600051 KBio1_000127 L000485 NCGC00015836-03 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one 11-[2-(4-methylpiperazino)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride NCGC00024297-05 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)- Pirenzepine (INN) API0006928 Prestwick2_000129 BSPBio_002945 SPBio_002117 CHEMBL9967 Tox21_110239_1 DSSTox_CID_3487 Gastrozepin KBio2_006994 LS-133128 11-[(4-Methyl-1-piperazinyl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one # NCGC00015836-06 [ Show all ]
Inchi Key	RMHMFHUVIITRHF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
PubChem CID	4848
ChEMBL	CHEMBL9967
IUPHAR	328
BindingDB	39341
DrugBank	DB00670
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.8 nM	PMID10571170	BindingDB,ChEMBL
IC50	120.0 nM	PMID3373484	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID3272174	BindingDB
Ki	5.2 nM	, Bioorg. Med. Chem. Lett., (1997) 7:8:979, PMID8464039, PMID1920350	BindingDB,ChEMBL
Ki	5.21 nM	PMID8464039, PMID1920350	ChEMBL
Ki	6.457 nM	PMID7932564, Bioorg. Med. Chem. Lett., (1995) 5:20:2325, PMID8246244, Bioorg. Med. Chem. Lett., (1995) 5:8:785	ChEMBL
Ki	6.46 nM	PMID8246244	BindingDB
Ki	6.5 nM	N/A	BindingDB
Ki	6.99 nM	PMID2547939	BindingDB
Ki	9.0 nM	PMID1646322	BindingDB
Ki	9.55 nM	PMID2250662	BindingDB
Ki	12.5893 - 15.8489 nM	PMID1325587, PMID2704370	IUPHAR
Ki	12.59 nM	PMID2188581	BindingDB
Ki	16.0 nM	PMID2704370	BindingDB
Ki	23.4 nM	PMID1310135	BindingDB
Ki	29.0 nM	PMID2066986	BindingDB,ChEMBL
Ki	1.25893e+17 nM	PMID9703467	ChEMBL
Potency	100.0 nM	PubChem BioAssay data set	ChEMBL
Potency	125.9 nM	PubChem BioAssay data set	ChEMBL

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