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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Mus musculus (Mouse)
Gene	Gpr183
Synonym	GPR183 G protein-coupled receptor 183 Epstein-Barr virus-induced gene 2 Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G protein-coupled receptor 2 EBI2 {ECO:0000250\|UniProtKB:P32249} EBI2 lymphocyte-specific G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
UniProt	Q3U6B2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259471
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3262876
Molecular formula	C24H24N2O3
IUPAC name	1-[4-(2-naphthalen-2-yloxyacetyl)piperazin-1-yl]-2-phenylethanone
Molecular weight	388.467
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.5
Synonyms	Oprea1_450805 AKOS000551057 1-{4-[2-(Naphthalen-2-yloxy)-acetyl]-piperazin-1-yl}-2-phenyl-ethanone BDBM50011717 MCULE-3484695850 STK146424 1-[4-(2-naphthalen-2-yloxyacetyl)piperazin-1-yl]-2-phenylethanone AT-057/43316524 2-(naphthalen-2-yloxy)-1-[4-(phenylacetyl)piperazin-1-yl]ethanone MolPort-001-536-112 AC1LLREA ZINC779577 1-[4-[2-(2-naphthyloxy)acetyl]piperazin-1-yl]-2-phenyl-ethanone BAS 04057156 2-naphthyl 2-oxo-2-[4-(phenylacetyl)-1-piperazinyl]ethyl ether [ Show all ]
Inchi Key	BPTCJGVNSUEYAM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24N2O3/c27-23(16-19-6-2-1-3-7-19)25-12-14-26(15-13-25)24(28)18-29-22-11-10-20-8-4-5-9-21(20)17-22/h1-11,17H,12-16,18H2
PubChem CID	1072081
ChEMBL	CHEMBL3262876
IUPHAR	N/A
BindingDB	50011717
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	204.0 nM	PMID24678947	BindingDB
IC50	204.17 nM	PMID24678947	ChEMBL
IC50	423.0 nM	PMID24678947	ChEMBL

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