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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Mus musculus (Mouse)
Gene	Hcar1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	343
Amino acid sequence	MDNGSCCLIEGEPISQVMPPLLILVFVLGALGNGIALCGFCFHMKTWKSSTIYLFNLAVADFLLMICLPLRTDYYLRRRHWIFGDIACRLVLFKLAMNRAGSIVFLTVVAVDRYFKVVHPHHMVNAISNRTAAATACVLWTLVILGTVYLLMESHLCVQGTLSSCESFIMESANGWHDVMFQLEFFLPLTIILFCSVNVVWSLRRRQQLTRQARMRRATRFIMVVASVFITCYLPSVLARLYFLWTVPTSACDPSVHTALHVTLSFTYLNSMLDPLVYYFSSPSLPKFYTKLTICSLKPKRPGRTKTRRSEEMPISNLCSKSSIDGANRSQRPSDGQWDLQVC
UniProt	Q8C131
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2146354
IUPHAR	311
DrugBank	N/A

Ligand

Name	3-Chloro-5-hydroxybenzoic acid
Molecular formula	C7H5ClO3
IUPAC name	3-chloro-5-hydroxybenzoic acid
Molecular weight	172.564
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.8
Synonyms	I01-11521 SC-73033 AK107678 KS-00000K5A SY025109 3-CHLORO-5-HYDROXY-BENZOIC ACID A829885 AN-40681 CTK4J9210 FT-0080917 RJOLIYHZZKAIET-UHFFFAOYSA-N X8059 3-hydroxy-5-chlorobenzoic acid ACMC-209lbs Benzoic acid, 3-chloro-5-hydroxy- K-9757 SCHEMBL1999585 53984-36-4 AKOS006293910 CHEMBL2146910 DB-006403 MFCD04114327 TC-120655 AB0033979 ANW-31910 FT-0650742 SBB052708 ZINC2599133 4CH-024347 AJ-43876 Benzoic acid,3-chloro-5-hydroxy- KB-31117 ST24042056 3-chloranyl-5-oxidanyl-benzoic acid 984C364 AM84171 CL8082 DTXSID50517335 MolPort-009-196-828 TS-02354 3-Chloro-5-hydroxybenzoic acid, >=97% (HPLC) AB18080 BDBM50391825 [ Show all ]
Inchi Key	RJOLIYHZZKAIET-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H5ClO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11)
PubChem CID	13071646
ChEMBL	CHEMBL2146910
IUPHAR	N/A
BindingDB	50391825
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	22000.0 nM	PMID24900524	BindingDB,ChEMBL

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