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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Mus musculus (Mouse)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNCDHCGKKGHDT
UniProt	P32304
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4764
IUPHAR	12
DrugBank	N/A

Ligand

Name	Fluspiperone
Molecular formula	C23H25F2N3O2
IUPAC name	1-(4-fluorophenyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight	413.469
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.1
Synonyms	AKOS030574103 Fluspiperone (USAN/INN) PDSP2_000964 {8-[3-(p-Fluorobenzoyl)propyl]-1-(p-fluorophenyl)-1,3,} {8-triazaspiro[4.5]decan-4-one} 4-(4-fluorophenyl)-8-[4-(4-fluorophenyl)-4-oxo-butyl]-2,4,8-triazaspiro[4.5]decan-1-one 8-(3-(p-Fluorobenzoyl)propyl)-1-(p-fluorophenyl)-1,3,8-triazaspiro(4.5)decan-4-one CHEMBL2104750 NSC 354855 SCHEMBL121266 AC1L4Y9O DTXSID20203495 NSC_166535 ZINC537753 1-(4-Fluorophenyl)-8-(4-(4-fluorophenyl)-4-oxobutyl)-1,3,8-triazaspiro[4.5]decan-4-one BDBM85032 Fluspiperone [USAN:INN] R 28,930 4-(4-fluorophenyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-2,4,8-triazaspiro[4.5]decan-1-one 8-[3-(p-Fluorobenzoyl)propyl]-1-(p-fluorophenyl)-1,8-triazaspiro[4.5]decan-4-one CTK5A2851 NSC-354855 UNII-V0Q53N427T 1,3,8-Triazaspiro(4.5)decan-4-one, 1-(4-fluorophenyl)-8-(4-(4-fluorophenyl)-4-oxobutyl)- AC1Q4NKH PDSP1_000980 {1,3,8-Triazaspiro[4.5]decan-4-one,} {1-(4-fluorophenyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-} 1-(4-fluorophenyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]-1,3,8-triazaspiro[4.5]decan-4-one CAS_54965-22-9 L000948 R-28930 54965-22-9 D02661 NSC354855 V0Q53N427T 1,8-Triazaspiro[4.5]decan-4-one, 1-(4-fluorophenyl)-8-[4-(4-fluorophenyl)-4-oxobutyl]- [ Show all ]
Inchi Key	RIOZXKPJYKSKJV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25F2N3O2/c24-18-5-3-17(4-6-18)21(29)2-1-13-27-14-11-23(12-15-27)22(30)26-16-28(23)20-9-7-19(25)8-10-20/h3-10H,1-2,11-16H2,(H,26,30)
PubChem CID	166535
ChEMBL	N/A
IUPHAR	N/A
BindingDB	85032
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	35.0 nM	PMID8935801	BindingDB

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