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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Mus musculus (Mouse)
Gene	Htr5a
Synonym	MR22 Htr5 5HT5- 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 5-HT5alpha 5-HT5A receptor 5-HT5A 5-HT-5A 5-HT-5 Serotonin receptor 5A [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProt	P30966
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3597
IUPHAR	10
DrugBank	N/A

Ligand

Name	CHEMBL126021
Molecular formula	C15H20N2O
IUPAC name	3-(5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl)propan-1-ol
Molecular weight	244.338
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	1.6
Synonyms	BDBM50132128 ZINC13476823 3-(5-Methyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl)-propan-1-ol
Inchi Key	REXSIWOVNKPQKA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H20N2O/c1-16-14-6-3-2-5-12(14)13-11-17(8-4-10-18)9-7-15(13)16/h2-3,5-6,18H,4,7-11H2,1H3
PubChem CID	44351116
ChEMBL	CHEMBL126021
IUPHAR	N/A
BindingDB	50132128
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1100.0 nM	PMID12930153	BindingDB,ChEMBL

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