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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Mus musculus (Mouse)
Gene	Htr5a
Synonym	MR22 Htr5 5HT5- 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 5-HT5alpha 5-HT5A receptor 5-HT5A 5-HT-5A 5-HT-5 Serotonin receptor 5A [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProt	P30966
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3597
IUPHAR	10
DrugBank	N/A

Ligand

Name	serotonin
Molecular formula	C10H12N2O
IUPAC name	3-(2-aminoethyl)-1H-indol-5-ol
Molecular weight	176.219
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.2
Synonyms	Bio1_000939 PDSP2_001496 BRN 0143524 Serotonin, analytical standard CH-132 Thrombocytin, 3-(\|A-Aminoethyl)-5-hydroxyindole, Thrombotonin GTPL5 2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid) I14-1899 333DO1RDJY KBio2_005040 5-Hydroxy-3-(beta-aminoethyl)indole KBioSS_000452 50-67-9 NCGC00015525-01 AN-41571 NCGC00015525-09 NCGC00142449-03 Bio2_000876 Prestwick2_000481 C-06146 SPBio_002262 CHEMBL39 Tryptamine, 5-hydroxy- EINECS 200-058-9 Hippophaine 3-(2-Aminoethyl)-1H-indol-5-ol K-9367 5-HT KBio3_000843 5-Hydroxyltryptamine Lopac-H-9523 AC1L1JTO NCGC00015525-04 API0006544 Oprea1_712368 BPBio1_000377 SCHEMBL1495 CC-21879 Substanz DS D0F6CD FCH832159 1H-Indol-5-ol, 3-(2-aminoethyl)- HMS1990H13 3-(b-Aminoethyl)-5-hydroxyindole KBio2_002472 5-Hydroxy-3-(.beta.-aminoethyl)indole KBioGR_000452 5-Hydroxytryptamine, 5-HT, Enteramine MCULE-8788459983 AKOS001484724 NCGC00015525-07 BDBM10755 Bio1_001428 Prestwick0_000481 BSPBio_000341 Serotonine CHEBI:28790 Thrombotonin Ds substance H-8000 3-(.beta.-Aminoethyl)-5-hydroxyindole IDI1_002151 KBio2_005588 5-hydroxy-tryptamine KBioSS_002479 6996AB NCGC00015525-02 Antemoqua NCGC00142449-01 NCGC00142449-04 Biomol-NT_000083 Prestwick3_000481 C00780 STK503758 cMAP_000059 UNII-333DO1RDJY Enteramin HMS1362H13 3-(2-Aminoethyl)-1H-indol-5-ol # KB-177045 5-Hta KBio3_000844 5-Hydroxytriptamine Lopac0_000607 AC1Q54C0 NCGC00015525-05 AX8011985 Bio1_000450 PDSP1_001512 BPBio1_001079 CCG-204696 Thrombocytin DB-051820 FT-0631212 1H-Indol-5-ol,3-(2-aminoethyl)- HMS3403H13 3-(beta-Aminoethyl)-5-hydroxyindole KBio2_003020 5-Hydroxy-3-(b-aminoethyl)indole KBioGR_002472 5-Hydroxytryptamine, free base MolPort-001-779-633 ALBB-006183 NCGC00015525-08 Bio2_000396 Prestwick1_000481 BSPBio_001112 SMP1_000272 TR-018115 DTXSID8075330 Hippophain 3-(2-Amino-ethyl)-1H-indol-5-ol Indol-5-ol, 3-(2-aminoethyl)- 5-22-12-00016 (Beilstein Handbook Reference) KBio2_007608 5-hydroxyl tryptamine L000078 6F7FD5B4-A558-45F0-A20A-2D068A3EFE6A NCGC00015525-03 Antemovis NCGC00142449-02 NCGC00142449-05 bmse000757 QZAYGJVTTNCVMB-UHFFFAOYSA-N CAS-153-98-0 Substance DS CTK4J2994 ZINC57058 Enteramine 14C-5-hydroxy tryptamine creatinine disulfate HMS1792H13 3-(2-Aminoethyl)indol-5-ol KBio2_000452 5-hydroxy tryptamine creatinine disulfate KBio3_002950 5-HYDROXYTRYPTAMINE LS-83647 AJ-09556 NCGC00015525-06 BCBcMAP01_000198 [ Show all ]
Inchi Key	QZAYGJVTTNCVMB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
PubChem CID	5202
ChEMBL	CHEMBL39
IUPHAR	5
BindingDB	10755
DrugBank	DB08839
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	150.0 nM	PMID12825922	BindingDB,ChEMBL
Ki	251.18 nM	PMID7984267, PMID1464308, PMID8450829	BindingDB
Ki	251.189 - 1000.0 nM	PMID8450829, PMID11343685, PMID8549774	IUPHAR
Ki	1100.0 nM	PMID8549774	BindingDB

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