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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	eucatropine
Molecular formula	C17H25NO3
IUPAC name	(1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate
Molecular weight	291.391
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	1,2,2,6-tetramethylpiperidin-4-yl 2-hydroxy-2-phenylacetate Benzeneacetic acid, .alpha.-hydroxy-, 1,2,2,6-tetramethyl-4-piperidinyl ester EINECS 202-900-0 FT-0712100 Prestwick3_000794 4SPJ105W8E BSPBio_000928 NCGC00179372-01 SPBio_002867 1,2,2,6-Tetramethyl-4-piperidinyl hydroxy(phenyl)acetate # AC1Q60W7 CHEMBL1618660 Eucatropinum [INN-Latin] Prestwick1_000794 100-91-4 BPBio1_001022 Eucatropina L000976 QSAVEGSLJISCDF-UHFFFAOYSA-N CAS_100-91-4 Eucatropine [INN:BAN] NSC_7534 UNII-4SPJ105W8E 1,2,2,6-Tetramethyl-4-piperidyl mandelate BDBM82377 DTXSID1048465 Euphthalmine Prestwick2_000794 2-hydroxy-2-phenylacetic acid (1,2,2,6-tetramethyl-4-piperidinyl) ester BRD-A37942872-003-03-2 Eucatropina [INN-Spanish] n-methyl-b-vinyldiacetonaikamine mandelate SCHEMBL132347 (1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate AC1L1OZA CHEBI:94371 Eucatropinum Prestwick0_000794 [ Show all ]
Inchi Key	QSAVEGSLJISCDF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25NO3/c1-12-10-14(11-17(2,3)18(12)4)21-16(20)15(19)13-8-6-5-7-9-13/h5-9,12,14-15,19H,10-11H2,1-4H3
PubChem CID	7534
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82377
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	323.59 nM	PMID2250662	BindingDB

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