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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesHomo sapiens (Human)
GeneHTR4
Synonym5-HT-4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
5-HT4 receptor
5-HT4
serotonin receptor 4
DiseaseN/A
Length388
Amino acid sequenceMDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProtQ13639
Protein Data BankN/A
GPCR-HGmod modelQ13639
3D structure modelThis predicted structure model is from GPCR-EXP Q13639.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1875
IUPHAR9
DrugBankBE0000084

Ligand

NameCHEMBL2179687
Molecular formulaC27H34N4O5
IUPAC name1-methyl-N-[[1-(4-phenylbutyl)piperidin-4-yl]methyl]indazole-3-carboxamide;oxalic acid
Molecular weight494.592
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogPNone
SynonymsN/A
Inchi KeyBMBHQHFPEKQDOU-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H32N4O.C2H2O4/c1-28-23-13-6-5-12-22(23)24(27-28)25(30)26-19-21-14-17-29(18-15-21)16-8-7-11-20-9-3-2-4-10-20;3-1(4)2(5)6/h2-6,9-10,12-13,21H,7-8,11,14-19H2,1H3,(H,26,30);(H,3,4)(H,5,6)
PubChem CID71457296
ChEMBLCHEMBL2179687
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition22.0 %PMID23043420ChEMBL
Inhibition64.0 %PMID23043420ChEMBL
Inhibition101.0 %PMID23043420ChEMBL

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