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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	MLS003107056
Molecular formula	C20H34O5
IUPAC name	7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]hept-5-enoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	2.7
Synonyms	2-azanyl-2-(hydroxymethyl)propane-1,3-diol;7-[3,5-bis(oxidanyl)-2-(3-oxidanyloct-1-enyl)cyclopentyl]hept-5-enoic acid 7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]hept-5-enoic acid ACMC-20n4t7 Prosta-5,13-dien-1-oicacid, 9,11,15-trihydroxy-, (5Z,8x,12x,13E)- (9CI) 159812-83-6 37658-84-7 8-iso-15(R)-Prostaglandin F2I+/- cid_44134913 2-amino-2-(hydroxymethyl)propane-1,3-diol;7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]hept-5-enoic acid 583E 9beta, 11alpha-PROSTAGLANDIN F2 ent-8-iso Prostaglandin F2I+/- 146388-90-1 214748-65-9 8-epi-Prostaglandin F2I+/- BDBM97180 SMR001821937 177020-26-7 5-trans Prostaglandin F2I(2) 9 beta, 11alpha-PGF2 CTK0H0425 2-amino-2-methylol-propane-1,3-diol;7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]hept-5-enoic acid 7-[3,5-Dihydroxy-2-(3-hydroxy-oct-1-enyl)-cyclopentyl]-hept-5-enoic acid AC1L18M0 15(R)-Prostaglandin F2I+/- 36150-02-4 8-iso Prostaglandin F2I(2) CHEMBL2220614 2-amino-2-(hydroxymethyl)propane-1,3-diol;7-[3,5-dihydroxy-2-(3-hydroxyoct-1-enyl)cyclopentyl]-5-heptenoic acid 5-trans Prostaglandin F2I+/- CTK8F7473 [ Show all ]
Inchi Key	PXGPLTODNUVGFL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)
PubChem CID	160
ChEMBL	N/A
IUPHAR	N/A
BindingDB	97180
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	964.0 nM	PMID10634944	PDSP

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