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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	CHEMBL301559
Molecular formula	C16H25NO
IUPAC name	(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	(R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol BDBM50054067 MFCD00153809 R(+)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (+)-7-OH-DPAT NCGC00015494-03 r-(+)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin (7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol AC1O7G3L Lopac-H-8653 PDSP1_001712 UNII-RR7D75YDF4 component BLYMJBIZMIGWFK-OAHLLOKOSA-N (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol.HCl CCG-204658 NCGC00015494-01 R(+)-7-Hydroxy(dipropylamino)tetralin hydrobromide (2R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol CTK5E9982 NCGC00024742-01 SCHEMBL7568447 (R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol AJ-46330 Lopac0_000569 PDSP2_001695 ZINC3870310 2-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-, (7R)- NCGC00015494-02 R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN& (7-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium(R(+)7OH-DPAT) 82730-72-1 Lopac-H-168 NCGC00162190-02 Tocris-0706 [ Show all ]
Inchi Key	BLYMJBIZMIGWFK-OAHLLOKOSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3/t15-/m1/s1
PubChem CID	6603867
ChEMBL	CHEMBL301559
IUPHAR	N/A
BindingDB	50054067
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	281.8 nM	PubChem BioAssay data set	ChEMBL
Potency	3981.1 nM	PubChem BioAssay data set	ChEMBL
Potency	5011.9 nM	PubChem BioAssay data set	ChEMBL

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