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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL301559
Molecular formula	C16H25NO
IUPAC name	(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol AC1O7G3L Lopac-H-8653 PDSP1_001712 UNII-RR7D75YDF4 component BLYMJBIZMIGWFK-OAHLLOKOSA-N (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol.HCl CCG-204658 NCGC00015494-01 R(+)-7-Hydroxy(dipropylamino)tetralin hydrobromide (2R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol CTK5E9982 NCGC00024742-01 SCHEMBL7568447 (R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol AJ-46330 Lopac0_000569 PDSP2_001695 ZINC3870310 2-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-, (7R)- NCGC00015494-02 R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN& (7-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium(R(+)7OH-DPAT) 82730-72-1 Lopac-H-168 NCGC00162190-02 Tocris-0706 (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ol BDBM50054067 MFCD00153809 R(+)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (+)-7-OH-DPAT NCGC00015494-03 r-(+)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin [ Show all ]
Inchi Key	BLYMJBIZMIGWFK-OAHLLOKOSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3/t15-/m1/s1
PubChem CID	6603867
ChEMBL	CHEMBL301559
IUPHAR	N/A
BindingDB	50054067
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	300.0 nM	PMID10956209	BindingDB,ChEMBL
Kd	400.0 nM	PMID10956209	BindingDB,ChEMBL
Kd	1000.0 nM	PMID10956209	BindingDB,ChEMBL
Kd	1100.0 nM	PMID10956209	BindingDB,ChEMBL
Ki	340.0 nM	PMID8230131	BindingDB,ChEMBL

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