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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL22215
Molecular formula	C19H19N
IUPAC name	2-methyl-9-phenyl-1,3,4,4a-tetrahydroindeno[2,1-c]pyridine
Molecular weight	261.368
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	3.2
Synonyms	1H-Indeno(2,1-c)pyridine, 2,3,4,4a-tetrahydro-2-methyl-9-phenyl- AC1Q1IXC 2-methyl-9-phenyl-1,3,4,4a-tetrahydroindeno[2,1-c]pyridine 60295-96-7 1h-indeno[2,1-c]pyridine, 2,3,4,4a-tetrahydro-2-methyl-9-phenyl- BDBM50089144 2-Methyl-9-phenyl-2,3,4,4a-tetrahydro-1H-indeno[2,1-c]pyridine CTK5B1260 AC1L4S61 1H-Indeno[2,1-c]pyridine,2,3,4,4a-tetrahydro-2-methyl-9-phenyl- Isophenindamine [ Show all ]
Inchi Key	BLHVBCNLGBEOEO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,16H,11-13H2,1H3
PubChem CID	162910
ChEMBL	CHEMBL22215
IUPHAR	N/A
BindingDB	50089144
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	28.0 nM	PMID10866399	BindingDB,ChEMBL

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