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Name | Alpha-2A adrenergic receptor |
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Species | Sus scrofa (Pig) |
Gene | ADRA2A |
Synonym | Alpha-2A adrenoceptor Alpha-2A adrenoreceptor Alpha-2AAR |
Disease | N/A for non-human GPCRs |
Length | 450 |
Amino acid sequence | MGSLQPEAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKAGGGGQQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAAALPGGAERRPNGLGPERGVGRVGAEAEPLPVQLNGAPGEPAPAGPRDADGLDLEESSSSEHAERPPGPRRSERGPRAKSKARASQVKPGDSLPRRGPGAPGPGAPATGAGEERGGVAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV |
UniProt | P18871 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2350 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEBI:48565 |
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Molecular formula | C21H26N2O3 |
IUPAC name | methyl 18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate |
Molecular weight | 354.45 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | ACon1_000583 beta-Yohimbin COYNANTHINE MCULE-4993391700 MFCD00066744 [ Show all ] |
Inchi Key | BLGXFZZNTVWLAY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3 |
PubChem CID | 2866 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 86230 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.37 nM | PMID7965790 | PDSP |
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