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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	FLUPHENAZINE
Molecular formula	C22H26F3N3OS
IUPAC name	2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Molecular weight	437.525
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.4
Synonyms	S79426A41Z Flufenazin 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride Sinqualone (TN) Fluorphenazine 4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol Spectrum5_001536 GTPL204 AB00053587_19 Trancin (TN) KBio2_002386 Apo-Fluphenazine KBioGR_002386 BPBio1_001187 MCULE-7579992672 NCGC00015436-06 Calmansial Moditen Hcl NSC 62323 cid_3372 1-(2-Hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine Phenothiazine, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-2-(trifluoromethyl)- Dapotum (TN) 10-(3'-(4"-(beta-Hydroxyethyl)-1"-piperazinyl)-propyl)-3-trifluoromethylphenothiazine Probes2_000295 DSSTox_CID_3068 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine SCHEMBL19221 flufenazine 4-(3-(-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol SPBio_001277 Fluphenazine (INN) SR-01000003048-5 HSDB 3334 AKOS001659031 Vespazine KBio2_005905 BDBM78433 L000257 NCGC00015436-01 BRD-K55127134-300-07-0 Modecate (TN) NCGC00015436-09 CCG-204645 Pacinol CTK8F9822 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- (9CI) Prestwick0_000320 1451-EP2272537A2 Prolixin (TN) DTXSID2023068 Enanthate (TN) 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol Sevinol Fluorfenazine pound (3/4)<4-(3-(2-Trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol Spectrum3_001420 Fluphenazinum [INN-Latin] AB00053587 Tox21_110146 KBio1_000511 Anatensol (TN) KBio3_002865 Biomol-NT_000023 LS-112565 NCGC00015436-04 C07010 Moditen (TN) NCGC00024429-04 CHEMBL726 Permitil (TN) D0P5SA 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- Prestwick3_000320 Deconoate (TN) 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol Prolixine (Salt/Mix) S94 Flufenazina 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride Siqualine Fluphenazin 47646-09-3 Spectrum_000289 HMS2089C16 AC1L1FSB Triflumethazine KBio2_003337 AX8130619 KBioSS_000769 BRD-K55127134-001-01-7 MFCD00242759 NCGC00015436-07 CAS-146-56-5 MolPort-001-727-938 NSC62323 cid_6602611 1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine Phthorphenazine Dapotum D (TN) 10-(3'-(4''-(beta-Hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine Prolixin DSSTox_GSID_23068 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol Sediten (TN) Flunanthate (TN) 4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol SPBio_002539 Fluphenazine [INN:BAN] A 4077 STK050763 Hydrochloride, Fluphenazine Anatensol Yespazine KBio2_007522 BG0198 Lopac-F-4765 NCGC00015436-02 BSPBio_000320 Moditen NCGC00015436-11 CHEBI:5123 Permitil D07977 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI) Prestwick1_000320 DB00623 1451-EP2298776A1 Prolixin Concentrate EINECS 200-702-9 S 94 Fludecate (TN) 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride Sevinol (TN) Fluorophenazine 4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol Spectrum4_000828 Ftorphenazine AB00053587-18 Tox21_110146_1 KBio2_000769 API0006719 KBioGR_001375 BPBio1_000352 Lyogen (TN) NCGC00015436-05 C22H26F3N3OS Moditen Enanthate Injection (TN) NINDS_000511 ChemDiv1_024180 0680AC Permitil Concentrate Dapotum 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- Probes1_000254 DivK1c_000511 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol # SBI-0050538.P003 Flufenazina [DCIT] Siqualon 69-23-8 SQ 4918 HMS655L02 AJ-72569 UNII-S79426A41Z KBio2_004954 BCP21399 KBioSS_002391 MRF-0000359 BRD-K55127134-300-05-4 MLS001076508 NCGC00015436-08 CAS-69-23-8 Omca (TN) cMAP_000035 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)- PLDUPXSUYLZYBN-UHFFFAOYSA-N Dapotum Injektion (TN) 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine Prolixin (Salt/Mix) DSSTox_RID_76862 2-(Trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-pipe razinyl)propyl)phenothiazine 2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride Selecten (TN) Fluorfenazine 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-Piperazineethanol Spectrum2_001199 Fluphenazinum A836405 Tensofin (Salt/Mix) IDI1_000511 Anatensol (Salt/Mix) ZINC19203912 KBio3_002320 BIDD:PXR0184 Lopac0_000555 NCGC00015436-03 BSPBio_003100 Moditen (Tabl or elixir) NCGC00024429-03 Permitil (Salt/Mix) D0B7SP 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)- Prestwick2_000320 Decanoate (TN) 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol Prolixine Elinol [ Show all ]
Inchi Key	PLDUPXSUYLZYBN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
PubChem CID	3372
ChEMBL	CHEMBL726
IUPHAR	204
BindingDB	78433
DrugBank	DB00623
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15.8489 nM	PMID7908055	IUPHAR
Ki	15.85 nM	PMID10821800	BindingDB
Ki	17.0 nM	PMID7908055	BindingDB

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