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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	CHEMBL387520
Molecular formula	C15H22N2O17P2S
IUPAC name	(2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Molecular weight	596.346
Hydrogen bond acceptor	18
Hydrogen bond donor	9
XlogP	-5.8
Synonyms	diphosphoric acid 1-alpha-D-glucopyranosuronic acid 2-((2''-thio)uridin-5''''-yl)ester BDBM50209667
Inchi Key	PIVUDWGDQYQGRN-LXQIFKJMSA-N
Inchi ID	InChI=1S/C15H22N2O17P2S/c18-5-1-2-17(15(37)16-5)12-9(22)6(19)4(31-12)3-30-35(26,27)34-36(28,29)33-14-10(23)7(20)8(21)11(32-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,26,27)(H,28,29)(H,16,18,37)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1
PubChem CID	44422899
ChEMBL	CHEMBL387520
IUPHAR	N/A
BindingDB	50209667
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	420.0 nM	PMID17407275	BindingDB,ChEMBL

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