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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Homo sapiens (Human)
Gene	GRM4
Synonym	mGluR4 mGlu4 receptor GPRC1D glutamate receptor
Disease	Anxiety disorder Neurological disease
Length	912
Amino acid sequence	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProt	Q14833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T99402
ChEMBL	CHEMBL2736
IUPHAR	292
DrugBank	BE0000833

Ligand

Name	MPPG
Molecular formula	C9H12NO5P
IUPAC name	2-amino-2-(4-phosphonophenyl)propanoic acid
Molecular weight	245.171
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-3.5
Synonyms	CTK8F0596 GTPL1415 RT-013949 API0007557 MFCD00672651 SR-01000597457-1 2-Amino-2-(4-phosphono-phenyl)-propionic acid(RS-MPPG) MPPG, >=97% (NMR), solid (RS)-?-Methyl-4-phosphonophenylglycine AC1N11KO D0D2GL J-010517 SCHEMBL12648709 169209-65-8 BDBM50089910 MolPort-003-983-629 2-amino-2-(4-phosphonophenyl)propanoic acid CHEMBL86508 DTXSID80398316 NCGC00024826-02 (RS)-\|A-Methyl-4-phosphonophenylglycine AKOS024458668 L000410 SR-01000597457 2-Amino-2-(4-phosphono-phenyl)-propionic acid BN0344 [ Show all ]
Inchi Key	PAONCRJPUQXPRW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H12NO5P/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H2,13,14,15)
PubChem CID	3972752
ChEMBL	CHEMBL86508
IUPHAR	1415
BindingDB	50089910
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9131252	BindingDB

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