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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392145
Molecular formula	C12H9NO5
IUPAC name	8-acetamido-4-oxochromene-2-carboxylic acid
Molecular weight	247.206
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	0.5
Synonyms	8-acetamido-4-oxo-4H-chromene-2-carboxylic acid 1443366-92-4 BDBM50436036
Inchi Key	OZSBJMMDIFFFMS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H9NO5/c1-6(14)13-8-4-2-3-7-9(15)5-10(12(16)17)18-11(7)8/h2-5H,1H3,(H,13,14)(H,16,17)
PubChem CID	71734941
ChEMBL	CHEMBL2392145
IUPHAR	N/A
BindingDB	50436036
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	24100.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	91.0 %	PMID23713606	ChEMBL
Ki	18500.0 nM	PMID23888932	BindingDB,ChEMBL

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