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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor 183
Species	Mus musculus (Mouse)
Gene	Gpr183
Synonym	GPR183 G protein-coupled receptor 183 Epstein-Barr virus-induced gene 2 Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G protein-coupled receptor 2 EBI2 {ECO:0000250\|UniProtKB:P32249} EBI2 lymphocyte-specific G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
UniProt	Q3U6B2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259471
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3262878
Molecular formula	C22H26N2O3
IUPAC name	1-[4-[2-(3,4-dimethylphenoxy)acetyl]piperazin-1-yl]-2-phenylethanone
Molecular weight	366.461
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.0
Synonyms	AKOS029737485 1-[4-[2-(3,4-dimethylphenoxy)acetyl]piperazin-1-yl]-2-phenyl-ethanone BDBM50011720
Inchi Key	OZFSNYWIRVFTSZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N2O3/c1-17-8-9-20(14-18(17)2)27-16-22(26)24-12-10-23(11-13-24)21(25)15-19-6-4-3-5-7-19/h3-9,14H,10-13,15-16H2,1-2H3
PubChem CID	86579897
ChEMBL	CHEMBL3262878
IUPHAR	N/A
BindingDB	50011720
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4341.0 nM	PMID24678947	ChEMBL
IC50	4365.0 nM	PMID24678947	BindingDB
IC50	4365.16 nM	PMID24678947	ChEMBL

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