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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Homo sapiens (Human)
Gene	GRM2
Synonym	mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor
Disease	Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder Psychiatric disorder Schizophrenia Alzheimer disease; Major depressive disorder [ Show all ]
Length	872
Amino acid sequence	MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	Q14416
Protein Data Bank	5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5cnj.
BioLiP	BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target Database	T62820
ChEMBL	CHEMBL5137
IUPHAR	290
DrugBank	N/A

Ligand

Name	D-2-aminoadipic acid
Molecular formula	C6H11NO4
IUPAC name	(2R)-2-aminohexanedioic acid
Molecular weight	161.157
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.1
Synonyms	Z2767445962 2-Aminohexanedioic acid (-)- and (+)- AK-44090 CHEBI:37025 D-Homoglutamic acid K303 MolPort-003-925-532 (2R)-2-aminohexanedioic acid AB0014153 AS-14204 CTK3J3823 FT-0636535 KSC493Q2H SC-10039 TR-032385 (R)-2-Aminohexanedioic acid AC1Q4UAX CA-639 D-2-Aminoadipic acid, 98% Hexanedioic acid, 2-amino-, (-)- and (+)- MFCD00063118 ZINC1678992 7620-28-2 alpha-Aminoadipate, D- D-\|A-Aminoadipic acid KB-50502 NCGC00015087-01 (R)-2-Amino-hexanedioic acid AC-22381 BC275520 D--Aminoadipic acid;(R)-2-Aminohexanedioic acid;H-D-Homoglu-OH H-D-2-Aad-OH Lopac-A-7275 SCHEMBL2022365 UNII-1K7B1OED4N component OYIFNHCXNCRBQI-SCSAIBSYSA-N (S)-2-Aminoadipic acid AJ-29561 CAS_542-32-5 D-a-Aminoadipic acid Hexanedioic acid, 2-amino-, (2R)- MFCD00063119 ANW-43726 CHEMBL1169505 DTXSID90227062 KS-00000JOF RTR-032385 (R)-2-Aminoadipic acid AC1L4WZI BDBM85356 H-D-Aad-OH M-3011 ST2402617 [ Show all ]
Inchi Key	OYIFNHCXNCRBQI-SCSAIBSYSA-N
Inchi ID	InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
PubChem CID	165627
ChEMBL	CHEMBL1169505
IUPHAR	N/A
BindingDB	85356
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID9357538, PMID8759641	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID9696422	BindingDB

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