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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-1 angiotensin II receptor
Species	Sus scrofa (Pig)
Gene	AGTR1
Synonym	Angiotensin II type-1 receptor AT1
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MILNSSTEDSIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKIADIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSENGSSSTKKSAPCTEVE
UniProt	P30555
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5743
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL518157
Molecular formula	C20H26N2O5S2
IUPAC name	butyl N-[3-(4-carbamoylphenyl)-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate
Molecular weight	438.557
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.5
Synonyms	butyl 3-(4-carbamoylphenyl)-5-isobutylthiophen-2-ylsulfonylcarbamate BDBM50251464
Inchi Key	OYEOYUQRRQBSEJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H26N2O5S2/c1-4-5-10-27-20(24)22-29(25,26)19-17(12-16(28-19)11-13(2)3)14-6-8-15(9-7-14)18(21)23/h6-9,12-13H,4-5,10-11H2,1-3H3,(H2,21,23)(H,22,24)
PubChem CID	44567709
ChEMBL	CHEMBL518157
IUPHAR	N/A
BindingDB	50251464
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	105.6 nM	PMID18599297	BindingDB,ChEMBL

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