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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392157
Molecular formula	C18H13NO6
IUPAC name	8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight	339.303
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.1
Synonyms	4-Oxo-8-(p-methoxybenzoylamino)-2-chromene-2-carboxylic acid BDBM50436009
Inchi Key	OVNIVCKVZJXFDK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H13NO6/c1-24-11-7-5-10(6-8-11)17(21)19-13-4-2-3-12-14(20)9-15(18(22)23)25-16(12)13/h2-9H,1H3,(H,19,21)(H,22,23)
PubChem CID	71735036
ChEMBL	CHEMBL2392157
IUPHAR	N/A
BindingDB	50436009
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	346.0 nM	PMID23713606, PMID23888932	BindingDB,ChEMBL
EC50	346.74 nM	PMID23713606	ChEMBL
EC50	347.0 nM	PMID23713606	BindingDB
EC50	472.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	104.0 %	PMID23713606	ChEMBL
Emax	115.0 %	PMID23713606	ChEMBL
Ki	221.0 nM	PMID23888932	BindingDB,ChEMBL

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