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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	CHEMBL596352
Molecular formula	C6H3Br3OS
IUPAC name	2-bromo-1-(3,4-dibromothiophen-2-yl)ethanone
Molecular weight	362.861
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.8
Synonyms	2-Bromo-1-(3,4-dibromothiophen-2-yl)ethanone ZINC2511029 BDBM50304456 CTK5I9323 63722-99-6 2-BROMO-1-(3,4-DIBROMO-THIOPHEN-2-YL)ETHANONE SCHEMBL6784082 AKOS018158421 [ Show all ]
Inchi Key	BJDAJEITGHVUFQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H3Br3OS/c7-1-4(10)6-5(9)3(8)2-11-6/h2H,1H2
PubChem CID	22712543
ChEMBL	CHEMBL596352
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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