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GPCR

NameG-protein coupled receptor 35
SpeciesHomo sapiens (Human)
GeneGPR35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A
Length309
Amino acid sequenceMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProtQ9HC97
Protein Data BankN/A
GPCR-HGmod modelQ9HC97
3D structure modelThis predicted structure model is from GPCR-EXP Q9HC97.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293267
IUPHAR102
DrugBankBE0005562

Ligand

NameCHEMBL2431134
Molecular formulaC26H26N4O2
IUPAC name6,7-dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
Molecular weight426.52
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP5.2
Synonyms6,7-dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
MolPort-000-810-051
BDBM50440747
ZINC2338076
488725-39-9
[ Show all ]
Inchi KeyOPQWCRILQBQTND-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H26N4O2/c1-31-23-17-21-22(18-24(23)32-2)27-25(19-9-5-3-6-10-19)28-26(21)30-15-13-29(14-16-30)20-11-7-4-8-12-20/h3-12,17-18H,13-16H2,1-2H3
PubChem CID1951822
ChEMBLCHEMBL2431134
IUPHARN/A
BindingDB50440747
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<40000.0 nMPMID24611085BindingDB,ChEMBL

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