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GLASS

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GPCR

Name	Histamine H4 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProt	Q91ZY1
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4468
IUPHAR	265
DrugBank	N/A

Ligand

Name	cinnamyl alcohol
Molecular formula	C9H10O
IUPAC name	(E)-3-phenylprop-2-en-1-ol
Molecular weight	134.178
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.9
Synonyms	bmse010256 ZINC1529427 Chnnamyl alcohol Cinnamyl alcohol, natural, 96%, FG EC 203-212-3 I792 (2E)-3-Phenyl-2-propen-1-ol LS-2357 .gamma.-Phenylallyl alcohol NSC-623440 3-Fenyl-2-propen-1-ol Q-100037 A800999 ST24022977 AJ-26595 trans cinnamyl alcohol trans-Cinnamyl-alcohol CCRIS 3191 cinnamyl-alcohol Epitope ID:150920 Jsp000446 (E)-3-phenyl-2-propen-1-ol(E)-cinnamyl alcohol MolPort-005-273-806 104-54-1 NSC8775 3-Phenyl-2-propenol SBB058645 AC1Q1HEH Styrone Alkohol skoricovy WLN: Q2U1R Cinnamyl alcohol, >=98%, FG E-cinnamyl alcohol HSDB 5011 KB-76100 (E)-Cinnam Alcohol NE10243 2-Propen-1-ol, 3-phenyl-, (E)- Phenylallyl alcohol 4407-36-7 SR-01000944721-1 ACN-046914 Styrylcarbinol BBL027413 BRN 1903999 cinnamic alcohol Cinnamyl alcohol, purum, >=97.0% (GC) EINECS 203-212-3 InChI=1/C9H10O/c10-8-4-7-9-5-2-1-3-6-9/h1-7,10H,8H2/b7-4 (2E)-3-phenylprop-2-en-1-ol MFCD00002921 1-06-00-00281 (Beilstein Handbook Reference) NSC-8775 3-Fenyl-2-propen-1-ol [Czech] RP17318 AB1003816 ST51036393 AK104332 Trans-3-phenylprop-2-en-1-ol UNII-SS8YOP444F CHEBI:17177 Cinnamyl alcohol, 98% CJ-23893 FEMA No. 2294 KB-236832 (E)-3-phenyl-prop-2-en-1-ol N1483 2-Propen-1-ol, 3-phenyl- OOCCDEMITAIZTP-QPJJXVBHSA-N 3-Phenylallyl alcohol SCHEMBL39219 AC1Q77UL Styryl alcohol Alkohol skoricovy [Czech] BDBM50310446 Zimtalcohol CHEMBL324794 Cinnamyl alcohol, analytical standard EBD2197996 I14-60909 KB-77822 (E)-cinnamyl alcohol NSC 8775 2-Propen-y1-ol, 3-phenyl- Propenoic acid, 3-phenyl-, (trans)- 4CN-1216 SS8YOP444F AI3-00949 TR-033383 C02394 Cinnamic alcohol (natural) Cinnamyl alcohol, Vetec(TM) reagent grade, 98% EN300-19335 J-525010 (E)-3-Phenyl-2-propen-1-ol MolPort-001-783-093 1-Phenylprop-1-en-3-ol NSC623440 3-PHENYL-2-PROPEN-1-OL RTR-033383 AC1NSTME STL146348 AKOS005265255 trans-cinnamyl alcohol W2111 CHEBI:33227 Cinnamyl alcohol, 98% trans E-Cinnamic alcohol gamma-Phenylallyl alcohol KB-288227 (E)-3-phenylprop-2-en-1-ol NCGC00166097-01 2-Propen-1-ol, 3-phenyl-, (2E)- Phenyl-2-propen-1-ol 3-phenylprop-2-en-1-ol SR-01000944721 AC1Q77UM Styryl carbinol AN-24683 [ Show all ]
Inchi Key	OOCCDEMITAIZTP-QPJJXVBHSA-N
Inchi ID	InChI=1S/C9H10O/c10-8-4-7-9-5-2-1-3-6-9/h1-7,10H,8H2/b7-4+
PubChem CID	5315892
ChEMBL	CHEMBL324794
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	33.5 %	PMID12443776	ChEMBL

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