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GPCR

NameD(2) dopamine receptor
SpeciesChlorocebus aethiops (Green monkey)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRSHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKNHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP52702
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5456
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL545460
Molecular formulaC20H23N3O2
IUPAC nameN-[[2-(3,4-dimethoxyphenyl)-1H-imidazol-5-yl]methyl]-N-methyl-1-phenylmethanamine
Molecular weight337.423
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.0
SynonymsCHEMBL1193969
BDBM50035378
2-(3,4-Dimethoxyphenyl)-5-[(N-benzyl-N-methylamino)methyl]-1H-imidazole
Benzyl-[2-(3,4-dimethoxy-phenyl)-3H-imidazol-4-ylmethyl]-methyl-amine; dihydrochloride
Inchi KeyONAIFKSIUPSKJT-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H23N3O2/c1-23(13-15-7-5-4-6-8-15)14-17-12-21-20(22-17)16-9-10-18(24-2)19(11-16)25-3/h4-12H,13-14H2,1-3H3,(H,21,22)
PubChem CID10042702
ChEMBLN/A
IUPHARN/A
BindingDB50035378
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3750.0 nMPMID7783157BindingDB

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